干旱区生态环境知识资源中心(Arid): Antioxidant activities of anastatin A & B derivatives and compound 38c's protective effect in a mouse model of CCl4-induced acute liver injury

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DOI	10.1039/d0ra00822b
	Antioxidant activities of anastatin A & B derivatives and compound 38c's protective effect in a mouse model of CCl4-induced acute liver injury
	Xiang, Cen 1; Cao, Menglin 1; Miao, Ai 1; Gao, Feng 1; Li, Xuzhe 1; Pan, Guojun 2; Zhang, Wenqiang 1; Zhang, Yongmin 1,3; Yu, Peng 1; Teng, Yuou 1
通讯作者	Zhang, Yongmin ; Yu, Peng ; Teng, Yuou
来源期刊	RSC ADVANCES
EISSN	2046-2069
出版年	2020
卷号	10 期号:24 页码:14337-14346
英文摘要	Anastatins A and B, two flavonoid compounds isolated from desert plant Anastatica hierochuntica, have protective activities for primary rat hepatocytes. Anastatins A and B, and their derivatives, were synthesized by our group previously. In this study, the antioxidant activity and cytotoxicity of these compounds were studied using chemical assessment methods, cell proliferation inhibition experiments, and cell oxidative damage models. The best compound, 38c, was used to study the hepatoprotection activity and mechanism by using a CCl4-induced liver injury model in mice. The results show that most of these flavonoid compounds have good antioxidant activity and low cytotoxicity in vitro. Among them, the most potent compound was 38c, which exhibited a protective effect on CCl4-induced hepatic injury by suppressing the amount of CYP2E1. These findings indicate that anastatin flavonoid derivatives have potential therapeutic utility against oxidative hepatic injury.
类型	Article
语种	英语
国家	Peoples R China ; France
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000528043700050
WOS关键词	OXIDATIVE STRESS ; FLAVONOIDS ; DISEASE ; ANTIBACTERIAL ; PLANTS ; CELLS
WOS类目	Chemistry, Multidisciplinary
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/315469
作者单位	1.Tianjin Univ Sci & Technol, Cooperat Base Food Nutr Safety & Med Chem, China Int Sci & Technol, Tianjin 300457, Peoples R China; 2.Shandong First Med Univ, Shandong Acad Med Sci, Sch Life Sci, Changcheng Rd 619, Tai An 271000, Shandong, Peoples R China; 3.Sorbonne Univ, CNRS, UMR8232, Inst Parisien Chim Mol, 4 Pl Jussieu, F-75005 Paris, France
推荐引用方式 GB/T 7714	Xiang, Cen,Cao, Menglin,Miao, Ai,et al. Antioxidant activities of anastatin A & B derivatives and compound 38c's protective effect in a mouse model of CCl4-induced acute liver injury[J],2020,10(24):14337-14346.
APA	Xiang, Cen.,Cao, Menglin.,Miao, Ai.,Gao, Feng.,Li, Xuzhe.,...&Teng, Yuou.(2020).Antioxidant activities of anastatin A & B derivatives and compound 38c's protective effect in a mouse model of CCl4-induced acute liver injury.RSC ADVANCES,10(24),14337-14346.
MLA	Xiang, Cen,et al."Antioxidant activities of anastatin A & B derivatives and compound 38c's protective effect in a mouse model of CCl4-induced acute liver injury".RSC ADVANCES 10.24(2020):14337-14346.