干旱区生态环境知识资源中心(Arid): Biopolymer Extracted from Anadenanthera colubrina (Red Angico Gum) Exerts Therapeutic Potential in Mice: Antidiarrheal Activity and Safety Assessment

Arid

DOI	10.3390/ph13010017
	Biopolymer Extracted from Anadenanthera colubrina (Red Angico Gum) Exerts Therapeutic Potential in Mice: Antidiarrheal Activity and Safety Assessment
	Araujo, Thiago S. L.1,2; de Oliveira, Taiane M.2; de Sousa, Nayara A.1,2; Souza, Luan K. M.1,2; Sousa, Francisca B. M.1,2; de Oliveira, Ana P.1,2; Nicolau, Lucas A. D.3; Silva, Alfredo A., V 3; Araujo, Alyne R.2; Magalhaes, Pedro J. C.3; Vasconcelos, Daniel F. P.1,2; de Jonge, Hugo R.4; Souza, Marcellus H. L. P.3; Silva, Durcilene A.1,2; Paula, Regina C. M.5; Medeiros, Jand Venes R.1,2
通讯作者	Medeiros, Jand Venes R.
来源期刊	PHARMACEUTICALS
EISSN	1424-8247
出版年	2020
卷号	13 期号:1
英文摘要	Anadenanthera colubrina var. cebil (Griseb.) Altschul (Fabaceae family), commonly known as the red angico tree, is a medicinal plant found throughout Brazil's semi-arid area. In this study, a chemical analysis was performed to investigate the antidiarrheal activity and safety profile of red angico gum (RAG), a biopolymer extracted from the trunk exudate of A. colubrina. Upon FT-IR spectroscopy, RAG showed bands in the regions of 1608 cm(-1), 1368 cm(-1), and 1029 cm(-1), which relate to the vibration of O-H water molecules, deformation vibration of C-O bands, and vibration of the polysaccharide C-O band, respectively, all of which are relevant to glycosidic bonds. The peak molar mass of RAG was 1.89 x 10(5) g/mol, with the zeta potential indicating electronegativity. RAG demonstrated high yield and solubility with a low degree of impurity. Pre-treatment with RAG reduced the total diarrheal stool and enteropooling. RAG also enhanced Na+/K+-ATPase activity and reduced gastrointestinal transit, and thereby inhibited intestinal smooth muscle contractions. Enzyme-Linked Immunosorbent Assay (ELISA) demonstrated that RAG can interact with GM1 receptors and can also reduce E. coli-induced diarrhea in vivo. Moreover, RAG did not induce any signs of toxicity in mice. These results suggest that RAG is a possible candidate for the treatment of diarrheal diseases.
英文关键词	polysaccharide Fabaceae diarrhea cholera Escherichia coli
类型	Article
语种	英语
国家	Brazil ; Netherlands
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000513160400004
WOS关键词	HEAT-LABILE ENTEROTOXIN ; SULFATED POLYSACCHARIDE FRACTION ; CASHEW GUM ; CHOLERA-TOXIN ; ANACARDIUM-OCCIDENTALE ; COMPLEX HETEROPOLYSACCHARIDE ; DUODENAL ANTIULCER ; BARK EXTRACT ; VAR. CEBIL ; IN-VITRO
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/315304
作者单位	1.Univ Fed Piaui, Northeast Biotechnol Network RENORBIO, BR-64049550 Teresina, PI, Brazil; 2.Fed Univ Parnaiba Delta, Biotechnol & Biodivers Ctr Res, BIOTEC, BR-64202020 Parnaiba, PI, Brazil; 3.Univ Fed Ceara, Dept Physiol & Pharmacol, BR-60430275 Fortaleza, Ceara, Brazil; 4.Erasmus MC, Dept Gastroenterol & Hepatol, NL-3000 CA Rotterdam, Netherlands; 5.Univ Fed Ceara, Dept Organ & Inorgan Chem, BR-60451970 Fortaleza, Ceara, Brazil
推荐引用方式 GB/T 7714	Araujo, Thiago S. L.,de Oliveira, Taiane M.,de Sousa, Nayara A.,et al. Biopolymer Extracted from Anadenanthera colubrina (Red Angico Gum) Exerts Therapeutic Potential in Mice: Antidiarrheal Activity and Safety Assessment[J],2020,13(1).
APA	Araujo, Thiago S. L..,de Oliveira, Taiane M..,de Sousa, Nayara A..,Souza, Luan K. M..,Sousa, Francisca B. M..,...&Medeiros, Jand Venes R..(2020).Biopolymer Extracted from Anadenanthera colubrina (Red Angico Gum) Exerts Therapeutic Potential in Mice: Antidiarrheal Activity and Safety Assessment.PHARMACEUTICALS,13(1).
MLA	Araujo, Thiago S. L.,et al."Biopolymer Extracted from Anadenanthera colubrina (Red Angico Gum) Exerts Therapeutic Potential in Mice: Antidiarrheal Activity and Safety Assessment".PHARMACEUTICALS 13.1(2020).