干旱区生态环境知识资源中心(Arid): Antibacterial Activity and Tolerance towards Heavy Metals by Endolithic and Epilithic Bacteria Isolated from Rocks of Nathiagali, Lower Himalaya, Pakistan

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DOI	10.17582/journal.pjz/20190128140128
	Antibacterial Activity and Tolerance towards Heavy Metals by Endolithic and Epilithic Bacteria Isolated from Rocks of Nathiagali, Lower Himalaya, Pakistan
	Ali, Barkat 1,2; Sajjad, Wasim 1,2,3; Khan, Imran 1; Rafiq, Muhammad 1; Zada, Sahib 1; Shah, Aamer Ali 1; Hasan, Fariha 1
通讯作者	Hasan, Fariha
来源期刊	PAKISTAN JOURNAL OF ZOOLOGY
ISSN	0030-9923
出版年	2020
卷号	52 期号:2 页码:465-475
英文摘要	Designing of new antimicrobial drugs is always needed to solve the problem of continue resistance emerging among microorganisms against antibiotics already in use. Microorganisms from unusual environments, such as reported from the surface and inside of rocks are a repository of certain metabolites that might be able to solve the problem of increasing resistance against antibiotics. The present study was designed to isolate endolithic and epilithic bacterial strains from the rapidly weathering rocks collected from Nathiagali, Pakistan to characterize and screen them for antimicrobial activity. The isolates were identified based on 16S rRNA sequence analysis. Antibacterial activity of the isolates was checked against ATCC strains E. coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Seven different types of antibiotic discs were used to check the intrinsic resistance of all the isolates to various antibiotics. Interestingly, most of the isolates were found resistant while only a few were susceptible, however, the isolates Lysinibacillus spp. N40 and Brevundomonas spp. P20 showed no activity at all. Increased levels of resistance to heavy metals such as; iron, arsenic, cadmium, chromium, and nickel were shown by strains like; Alcaligenes spp. N14 and N21, Bordetella spp. N30 and Streptomyces spp. N28. Alcaligenes spp. N27 and Lysinibacillus spp. P17 showed strong activity against all the three ATCC strains. The study concludes that the bacteria isolated from the rocks having substantial resistance to heavy metals are also showing good antibacterial activity as well as, and they are also potential candidates for the applications in pharmaceutical as well as environmental research.
英文关键词	Endoliths Epiliths Antibiotics Antibiotic resistance Heavy metal resistance
类型	Article
语种	英语
国家	Pakistan ; Peoples R China
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000514817800005
WOS关键词	MICROBIAL COMMUNITY ; ROSS DESERT ; ALGAE ; MICROORGANISMS ; CYANOBACTERIA ; IDENTIFICATION ; EXTREMOPHILES ; TRAVERTINE ; MICROSCOPY ; HABITATS
WOS类目	Zoology
WOS研究方向	Zoology
来源机构	中国科学院地质与地球物理研究所
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/315269
作者单位	1.Quaid I Azam Univ, Fac Biol Sci, Dept Microbiol, Appl Environm & Geomicrobiol Lab, Islamabad 45320, Pakistan; 2.Univ Chinese Acad Sci, Northwest Inst Ecoenvironm & Resources, State Key Lab Cryosphere Sci, Lanzhou, Peoples R China; 3.Chinese Acad Sci, Inst Geol & Geophys, Key Lab Petr Resources, Key Lab Petr Resources Res, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Ali, Barkat,Sajjad, Wasim,Khan, Imran,et al. Antibacterial Activity and Tolerance towards Heavy Metals by Endolithic and Epilithic Bacteria Isolated from Rocks of Nathiagali, Lower Himalaya, Pakistan[J]. 中国科学院地质与地球物理研究所,2020,52(2):465-475.
APA	Ali, Barkat.,Sajjad, Wasim.,Khan, Imran.,Rafiq, Muhammad.,Zada, Sahib.,...&Hasan, Fariha.(2020).Antibacterial Activity and Tolerance towards Heavy Metals by Endolithic and Epilithic Bacteria Isolated from Rocks of Nathiagali, Lower Himalaya, Pakistan.PAKISTAN JOURNAL OF ZOOLOGY,52(2),465-475.
MLA	Ali, Barkat,et al."Antibacterial Activity and Tolerance towards Heavy Metals by Endolithic and Epilithic Bacteria Isolated from Rocks of Nathiagali, Lower Himalaya, Pakistan".PAKISTAN JOURNAL OF ZOOLOGY 52.2(2020):465-475.