干旱区生态环境知识资源中心(Arid): Gli3 is a Key Factor in the Schwann Cells from Both Intact and Injured Peripheral Nerves

Arid

DOI	10.1016/j.neuroscience.2020.02.036
	Gli3 is a Key Factor in the Schwann Cells from Both Intact and Injured Peripheral Nerves
	Yamada, Yurie 1,2,3; Trakanant, Supaluk 1,2; Nihara, Jun 1,2,4; Kudo, Takehisa 1,2; Seo, Kenji 2,5; Saeki, Makio 2,6; Kurose, Masayuki 2,7; Matsumaru, Daisuke 8; Maeda, Takeyasu 1,2; Ohazama, Atsushi 1,2
通讯作者	Yamada, Yurie ; Ohazama, Atsushi
来源期刊	NEUROSCIENCE
ISSN	0306-4522
EISSN	1873-7544
出版年	2020
卷号	432 页码:229-239
英文摘要	Hedgehog (Hh) signaling has been shown to be involved in regulating both intact and injured peripheral nerves. Therefore, it is critical to understand how Hh signaling is regulated in the peripheral nerve. One of the transcription factors of the Hh signaling pathway, Gli3, functions as both a repressor and an activator of Hh signaling activity. However, it remains unclear whether Gli3 is involved in controlling the intact and/or injured peripheral nerves. We found that Gli3 act as a repressor in the Schwann cells (SCs) of intact sciatic nerves. Although Dhh and Ptch1 expression were present, Hh signaling was not activated in these SCs. Moreover, heterozygous Gli3 mutation (Gli3(-/+)) induced ectopic Hh signaling activity in SCs. Hh signaling was thus suppressed by Gli3 in the SCs of intact sciatic nerves. Minor morphological changes were observed in the intact nerves from Gli3(-/+) mice. Gli3 expression was significantly decreased following injury and ligand expression switched from Dhh to Shh, which activated Hh signaling in SCs from wild-type mice. Changes of these ligands was found to be important for nerve regeneration in which the downregulation of Gli3 was also involved. In fact, Gli3(-/+) mice exhibited accelerated ligand switching and subsequent nerve regeneration. Both suppression of Hh signaling with Gli3 in the intact nerves and activation of Hh signaling without Gli3 in the injured nerve were observed in the SCs in an autocrine manner. Thus, Gli3 is a key factor in the control of intact peripheral nerve homeostasis and nerve regeneration. (C) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.
英文关键词	Hh signaling Gli3 peripheral nerves regeneration
类型	Article
语种	英语
国家	Japan
收录类别	SCI-E
WOS记录号	WOS:000522084600020
WOS关键词	SONIC HEDGEHOG ; DESERT-HEDGEHOG ; STEM-CELL ; EXPRESSION ; MUTATION
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/315232
作者单位	1.Niigata Univ, Fac Dent, Div Oral Anat, Niigata, Japan; 2.Niigata Univ, Grad Sch Med & Dent Sci, Niigata, Japan; 3.Niigata Univ, Fac Dent, Ctr Adv Oral Sci, Niigata, Japan; 4.Niigata Univ, Fac Dent, Div Orthodont, Niigata, Japan; 5.Niigata Univ, Fac Dent, Div Dent Anesthesiol, Niigata, Japan; 6.Niigata Univ, Fac Dent, Div Dent Pharmacol, Niigata, Japan; 7.Niigata Univ, Fac Dent, Div Oral Physiol, Niigata, Japan; 8.Wakayama Med Univ, Inst Adv Med, Dept Dev Genet, Wakayama, Japan
推荐引用方式 GB/T 7714	Yamada, Yurie,Trakanant, Supaluk,Nihara, Jun,et al. Gli3 is a Key Factor in the Schwann Cells from Both Intact and Injured Peripheral Nerves[J],2020,432:229-239.
APA	Yamada, Yurie.,Trakanant, Supaluk.,Nihara, Jun.,Kudo, Takehisa.,Seo, Kenji.,...&Ohazama, Atsushi.(2020).Gli3 is a Key Factor in the Schwann Cells from Both Intact and Injured Peripheral Nerves.NEUROSCIENCE,432,229-239.
MLA	Yamada, Yurie,et al."Gli3 is a Key Factor in the Schwann Cells from Both Intact and Injured Peripheral Nerves".NEUROSCIENCE 432(2020):229-239.