干旱区生态环境知识资源中心(Arid): Comparative and population genomics approaches reveal the basis of adaptation to deserts in a small rodent

Arid

DOI	10.1111/mec.15401
	Comparative and population genomics approaches reveal the basis of adaptation to deserts in a small rodent
	Tigano, Anna 1,2; Colella, Jocelyn P.1,2; MacManes, Matthew D.1,2
通讯作者	Tigano, Anna
来源期刊	MOLECULAR ECOLOGY
ISSN	0962-1083
EISSN	1365-294X
出版年	2020
卷号	29 期号:7 页码:1300-1314
英文摘要	Organisms that live in deserts offer the opportunity to investigate how species adapt to environmental conditions that are lethal to most plants and animals. In the hot deserts of North America, high temperatures and lack of water are conspicuous challenges for organisms living there. The cactus mouse (Peromyscus eremicus) displays several adaptations to these conditions, including low metabolic rate, heat tolerance, and the ability to maintain homeostasis under extreme dehydration. To investigate the genomic basis of desert adaptation in cactus mice, we built a chromosome-level genome assembly and resequenced 26 additional cactus mouse genomes from two locations in southern California (USA). Using these data, we integrated comparative, population, and functional genomic approaches. We identified 16 gene families exhibiting significant contractions or expansions in the cactus mouse compared to 17 other Myodontine rodent genomes, and found 232 sites across the genome associated with selective sweeps. Functional annotations of candidate gene families and selective sweeps revealed a pervasive signature of selection at genes involved in the synthesis and degradation of proteins, consistent with the evolution of cellular mechanisms to cope with protein denaturation caused by thermal and hyperosmotic stress. Other strong candidate genes included receptors for bitter taste, suggesting a dietary shift towards chemically defended desert plants and insects, and a growth factor involved in lipid metabolism, potentially involved in prevention of dehydration. Understanding how species adapted to deserts will provide an important foundation for predicting future evolutionary responses to increasing temperatures, droughts and desertification in the cactus mouse and other species.
英文关键词	bitter taste receptor hyperosmotic stress Peromyscus eremicus ribosomal protein selective sweeps thermal stress
类型	Article
语种	英语
国家	USA
开放获取类型	hybrid, Green Submitted, Green Published
收录类别	SCI-E
WOS记录号	WOS:000528214700007
WOS关键词	SELECTIVE SWEEPS ; GENETIC-BASIS ; DIVERSIFICATION ; HYBRIDIZATION ; PROVIDES ; EVOLUTION ; ALIGNMENT ; PATTERNS ; MAMMALS ; SYSTEM
WOS类目	Biochemistry & Molecular Biology ; Ecology ; Evolutionary Biology
WOS研究方向	Biochemistry & Molecular Biology ; Environmental Sciences & Ecology ; Evolutionary Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/315189
作者单位	1.Univ New Hampshire, Dept Mol Cellular & Biomed Sci, Durham, NH 03824 USA; 2.Univ New Hampshire, Hubbard Ctr Genome Studies, Durham, NH 03824 USA
推荐引用方式 GB/T 7714	Tigano, Anna,Colella, Jocelyn P.,MacManes, Matthew D.. Comparative and population genomics approaches reveal the basis of adaptation to deserts in a small rodent[J],2020,29(7):1300-1314.
APA	Tigano, Anna,Colella, Jocelyn P.,&MacManes, Matthew D..(2020).Comparative and population genomics approaches reveal the basis of adaptation to deserts in a small rodent.MOLECULAR ECOLOGY,29(7),1300-1314.
MLA	Tigano, Anna,et al."Comparative and population genomics approaches reveal the basis of adaptation to deserts in a small rodent".MOLECULAR ECOLOGY 29.7(2020):1300-1314.