干旱区生态环境知识资源中心(Arid): Downsizing Class II Lasso Peptides: Genome Mining-Guided Isolation of Huascopeptin Containing the First Gly1-Asp7 Macrocycle

Arid

DOI	10.1021/acs.joc.9b02231
	Downsizing Class II Lasso Peptides: Genome Mining-Guided Isolation of Huascopeptin Containing the First Gly1-Asp7 Macrocycle
	Cortes-Albayay, Carlos 2; Jarmusch, Scott A.1; Trusch, Franziska 3,4; Ebel, Rainer 1; Andrews, Barbara A.2; Jaspars, Marcel 1; Asenjo, Juan A.2
通讯作者	Jaspars, Marcel ; Asenjo, Juan A.
来源期刊	JOURNAL OF ORGANIC CHEMISTRY
ISSN	0022-3263
EISSN	1520-6904
出版年	2020
卷号	85 期号:3 页码:1661-1667
英文摘要	A new lasso peptide, huascopeptin, was isolated following genome-mined discovery of a new biosynthetic gene cluster in extremotolerant Streptomyces huasconensis HST28(T) from Salar de Huasco, Atacama Desert, Chile. Compound 1 is a 13-residue class II lasso peptide containing a novel Gly1-Asp7 macrolactam ring, a three-residue loop, and a three-residue tail, making it the smallest lasso peptide isolated to date. The lasso structure was confirmed using NOE restraint-based molecular dynamics simulations.
类型	Article
语种	英语
国家	Scotland ; Chile
开放获取类型	Green Accepted
收录类别	SCI-E
WOS记录号	WOS:000513080700035
WOS关键词	NATURAL-PRODUCTS ; BIOSYNTHESIS ; DIVERSITY ; DISCOVERY ; LEADER ; LIGHT ; TOOL
WOS类目	Chemistry, Organic
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/315043
作者单位	1.Univ Aberdeen, Marine Biodiscovery Ctr, Dept Chem, Old Aberdeen AB24 3UE, Scotland; 2.Univ Chile, Ctr Biotechnol & Bioengn, CeBiB, Dept Chem Engn Biotechnol & Mat, Santiago 8370450, Chile; 3.Univ Aberdeen, Inst Med Sci, Aberdeen AB2S 2ZD, Foresterhill, Scotland; 4.Univ Dundee, Div Plant Sci, Coll Life Sci, JHI, Dundee DD2 5DA, Scotland
推荐引用方式 GB/T 7714	Cortes-Albayay, Carlos,Jarmusch, Scott A.,Trusch, Franziska,et al. Downsizing Class II Lasso Peptides: Genome Mining-Guided Isolation of Huascopeptin Containing the First Gly1-Asp7 Macrocycle[J],2020,85(3):1661-1667.
APA	Cortes-Albayay, Carlos.,Jarmusch, Scott A..,Trusch, Franziska.,Ebel, Rainer.,Andrews, Barbara A..,...&Asenjo, Juan A..(2020).Downsizing Class II Lasso Peptides: Genome Mining-Guided Isolation of Huascopeptin Containing the First Gly1-Asp7 Macrocycle.JOURNAL OF ORGANIC CHEMISTRY,85(3),1661-1667.
MLA	Cortes-Albayay, Carlos,et al."Downsizing Class II Lasso Peptides: Genome Mining-Guided Isolation of Huascopeptin Containing the First Gly1-Asp7 Macrocycle".JOURNAL OF ORGANIC CHEMISTRY 85.3(2020):1661-1667.