干旱区生态环境知识资源中心(Arid): Comparing SPM12 and CAT12 segmentation pipelines: a brain tissue volume-based age and Alzheimer's disease study

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DOI	10.1016/j.jneumeth.2019.108565
	Comparing SPM12 and CAT12 segmentation pipelines: a brain tissue volume-based age and Alzheimer's disease study
	Tavares, Vania 1,2; Prata, Diana 1,3,4; Ferreira, Hugo Alexandre 1
通讯作者	Tavares, Vania
来源期刊	JOURNAL OF NEUROSCIENCE METHODS
ISSN	0165-0270
EISSN	1872-678X
出版年	2020
卷号	334
英文摘要	Background: Brain volumes have been used as research biomarkers both in health and in Alzheimer's disease (AD). In order to improve the comparability between studies and aid future analytical software platform choice in the research setting, here we compare two segmentation pipelines of structural brain magnetic resonance imaging(sMRI): the SPM12 toolbox, and a SPM12 add-on, the CAT12 toolbox. Methods: We segmented 1.5T and 3T T1-weighted sMRI images (from the OASIS-brain database) using both pipelines and compared them in terms of their impact on: 1)the effect of age on the total grey matter(GM) and white matter(WM), and on the hippocampi GM volumes in a healthy sample(n = 238); 2)the effect of AD diagnosis on the same volume measures; and 3)the accuracy of each volume measure detecting diagnosis (100 patients with AD and 78 age- and gender-matched healthy subjects). Results and comparison between methods: Our results demonstrated that: 1)volume estimates from SPM12 were highly correlated with the ones from CAT12, albeit absolute differences between pipelines were tissue specific; 2)the choice of pipeline modulated the effect of age on all volume measures and of diagnosis on hippocampi GM volumes computed from 3 T data; and 3)pipeline had no impact on the accuracy of any brain volume measure detecting AD diagnosis. Conclusions: Our findings indicate that other studies should take these pipeline effects on age and AD diagnosis, into account, for improved comparability in previous literature. Additionally, we encourage future studies to use CAT12 as this is a more advanced and computationally efficient brain segmentation tool.
英文关键词	Brain tissue segmentation SPM12 CAT12 Alzheimer's disease diagnosis Biomarker Aging
类型	Article
语种	英语
国家	Portugal ; England
收录类别	SCI-E
WOS记录号	WOS:000526049200008
WOS关键词	OPEN ACCESS SERIES ; MRI DATA ; DEMENTIA
WOS类目	Biochemical Research Methods ; Neurosciences
WOS研究方向	Biochemistry & Molecular Biology ; Neurosciences & Neurology
来源机构	University of London
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/315041
作者单位	1.Univ Lisbon, Inst Biofis & Engn Biomed, Fac Ciencias, Lisbon, Portugal; 2.Univ Lisbon, Fac Med, Lisbon, Portugal; 3.IUL, CIS, ISCTE, Lisbon, Portugal; 4.Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Neuroimaging, London, England
推荐引用方式 GB/T 7714	Tavares, Vania,Prata, Diana,Ferreira, Hugo Alexandre. Comparing SPM12 and CAT12 segmentation pipelines: a brain tissue volume-based age and Alzheimer's disease study[J]. University of London,2020,334.
APA	Tavares, Vania,Prata, Diana,&Ferreira, Hugo Alexandre.(2020).Comparing SPM12 and CAT12 segmentation pipelines: a brain tissue volume-based age and Alzheimer's disease study.JOURNAL OF NEUROSCIENCE METHODS,334.
MLA	Tavares, Vania,et al."Comparing SPM12 and CAT12 segmentation pipelines: a brain tissue volume-based age and Alzheimer's disease study".JOURNAL OF NEUROSCIENCE METHODS 334(2020).