干旱区生态环境知识资源中心(Arid): Gene mapping and genomic prediction of bull fertility using sex chromosome markers

Arid

DOI	10.3168/jds.2019-17767
	Gene mapping and genomic prediction of bull fertility using sex chromosome markers
	Pacheco, Hendyel A.1; Rezende, Fernanda M.1,2; Penagaricano, Francisco 1,3
通讯作者	Penagaricano, Francisco
来源期刊	JOURNAL OF DAIRY SCIENCE
ISSN	0022-0302
EISSN	1525-3198
出版年	2020
卷号	103 期号:4 页码:3304-3311
英文摘要	Service sire has been recognized as an important factor affecting dairy herd fertility. Our group has reported promising results on gene mapping and genomic prediction of dairy bull fertility using autosomal SNP markers. Little is known, however, about the genetic contribution of sex chromosomes, which are enriched in genes related to sexual development and reproduction. As such, the main goal of this study was to investigate the effect of SNP markers on X and Y chromosomes (BTAX and BTAY, respectively) on sire conception rate (SCR) in US Holstein bulls. The analysis included a total of 5,014 bulls with SCR records and genotypes for roughly 291k SNP located on the autosomes, 1.5k SNP located on the pseudoautosomal region (PAR), 13.7k BTAX-specific SNP, and 24 BTAY-specific SNP. We first performed genomic scans of the sex chromosornes, arid then we evaluated the genomic prediction of SCR including BTAX SNP markers in the predictive models. Two markers located on PAR and 3 markers located on the X-specific region showed significant associations with sire fertility. Interestingly, these regions harbor genes, such as FAM9B, TBL1X, and PIH1D3, that are directly implicated in testosterone concentration, spermatogenesis, and sperm motility. On the other hand, BTAY showed very low genetic variability, and none of the segregating markers were associated with SCR. Notably, model predictive ability was largely improved by including BTAX markers. Indeed, the combination of autosomal with BTAX SNP delivered predictive correlations around 0.343, representing an increase in accuracy of about 7.5% compared with the standard whole autosomal genome approach. Overall, this study provides evidence of the importance of both PAR and X-specific regions in male fertility in dairy cattle. These findings may help to improve conception rates in dairy herds through accurate genome-guided decisions on bull fertility.
英文关键词	genomic prediction pseudoautosomal region sire conception rate X chromosome
类型	Article
语种	英语
国家	USA ; Brazil
开放获取类型	hybrid
收录类别	SCI-E
WOS记录号	WOS:000519992900032
WOS关键词	AXONEMAL DYNEIN ; Y-CHROMOSOME ; REGRESSION ; SELECTION ; COMPLEX ; REGION ; TESTIS
WOS类目	Agriculture, Dairy & Animal Science ; Food Science & Technology
WOS研究方向	Agriculture ; Food Science & Technology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/314930
作者单位	1.Univ Florida, Dept Anim Sci, Gainesville, FL 32611 USA; 2.Univ Fed Uberlandia, Fac Med Vet, BR-38400902 Uberlandia, MG, Brazil; 3.Univ Florida, Genet Inst, Gainesville, FL 32610 USA
推荐引用方式 GB/T 7714	Pacheco, Hendyel A.,Rezende, Fernanda M.,Penagaricano, Francisco. Gene mapping and genomic prediction of bull fertility using sex chromosome markers[J],2020,103(4):3304-3311.
APA	Pacheco, Hendyel A.,Rezende, Fernanda M.,&Penagaricano, Francisco.(2020).Gene mapping and genomic prediction of bull fertility using sex chromosome markers.JOURNAL OF DAIRY SCIENCE,103(4),3304-3311.
MLA	Pacheco, Hendyel A.,et al."Gene mapping and genomic prediction of bull fertility using sex chromosome markers".JOURNAL OF DAIRY SCIENCE 103.4(2020):3304-3311.