干旱区生态环境知识资源中心(Arid): Stereochemical determination of four 10-membered ring resorcylic acid lactones from the desert plant endophytic fungus Chaetosphaeronema hispidulum

Arid

DOI	10.1038/s41429-020-0297-2
	Stereochemical determination of four 10-membered ring resorcylic acid lactones from the desert plant endophytic fungus Chaetosphaeronema hispidulum
	Zheng, Min 1,2; Xu, Zhen-Lu 2,3,4; Yang, Run-Mei 2; Hu, Shen-Cai 1; Ding, Gang 2; Qin, Jian-Chun 5; Zhang, Yong-Gang 3,4
通讯作者	Hu, Shen-Cai ; Ding, Gang ; Zhang, Yong-Gang
来源期刊	JOURNAL OF ANTIBIOTICS
ISSN	0021-8820
EISSN	1881-1469
出版年	2020
卷号	73 期号:7 页码:471-474
英文摘要	Four 10-membered ring resorcylic acid lactones (RALs) including a new compound hispidulactone F (1) and three known analogs hispidulactone B (2), 2 R, 4R-sonnerlactone (3), and 2 R, 4S-sonnerlactone (4) were isolated from the special bioenvironmental desert plant endophytic fungus Chaetosphaeronema hispidulum. The structure of the new compound hispidulactone F (1) was determined by extensive spectra analysis including HR-ESI-MS, NMR (H-1, C-13, H-1-H-1 COSY, HSQC, and HMBC). Hispidulactone F (1) and hispidulactone B (2) were a pair of stereoisomers at C-3, whereas 2 R, 4R-sonnerlactone (3) and 2 R, 4S-sonnerlactone (4) were another pair of stereoisomers at C-4. The stereochemistries of the hydroxyl groups at C-3 in 1 and 2, and at C-4 in 3 and 4 were first determined by modified Mosher's reactions. Thus, the absolute configuration C-3 in hispidulactone B (2) was not right in our previous report, and was rectified to be R. Compounds 1 and 4 were evaluated for their cytotoxic effects on the proliferation of HepG2. The possible biosynthetic pathway of compounds 1-4 was also presented.
类型	Article
语种	英语
国家	Peoples R China
收录类别	SCI-E
WOS记录号	WOS:000518882700001
WOS类目	Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
WOS研究方向	Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/314860
作者单位	1.Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China; 2.Chinese Acad Med Sci & Peking Union Med Coll, Key Lab Bioact Subst & Resources Utilizat Chinese, Inst Med Plant Dev, Minist Educ, Beijing 100193, Peoples R China; 3.Qilu Univ Technol, Shandong Acad Sci, Inst Biol, Jinan 250103, Shandong, Peoples R China; 4.Shandong Normal Univ, Coll Life Sci, Jinan 250014, Shandong, Peoples R China; 5.Jilin Univ, Coll Plant Sci, Changchun 130062, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Min,Xu, Zhen-Lu,Yang, Run-Mei,et al. Stereochemical determination of four 10-membered ring resorcylic acid lactones from the desert plant endophytic fungus Chaetosphaeronema hispidulum[J],2020,73(7):471-474.
APA	Zheng, Min.,Xu, Zhen-Lu.,Yang, Run-Mei.,Hu, Shen-Cai.,Ding, Gang.,...&Zhang, Yong-Gang.(2020).Stereochemical determination of four 10-membered ring resorcylic acid lactones from the desert plant endophytic fungus Chaetosphaeronema hispidulum.JOURNAL OF ANTIBIOTICS,73(7),471-474.
MLA	Zheng, Min,et al."Stereochemical determination of four 10-membered ring resorcylic acid lactones from the desert plant endophytic fungus Chaetosphaeronema hispidulum".JOURNAL OF ANTIBIOTICS 73.7(2020):471-474.