干旱区生态环境知识资源中心(Arid): Hispidulones A and B, two new phenalenone analogs from desert plant endophytic fungus Chaetosphaeronema hispidulum

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DOI	10.1038/s41429-019-0247-z
	Hispidulones A and B, two new phenalenone analogs from desert plant endophytic fungus Chaetosphaeronema hispidulum
	Zhang, Xiaoyan 1,2; Tan, Xiangmei 1,2; Li, Yuanyuan 1,2; Wang, Yanduo 1,2; Yu, Meng 1,2; Qing, Jianchun 3; Sun, Bingda 4; Niu, Shubin 5; Ding, Gang 1,2
通讯作者	Ding, Gang
来源期刊	JOURNAL OF ANTIBIOTICS
ISSN	0021-8820
EISSN	1881-1469
出版年	2020
卷号	73 期号:1 页码:56-59
英文摘要	Two new phenalenone analogs hispidulones A (1) and B (2) were isolated from the specially bioenvironmental desert plant endophytic fungus Chaetosphaeronema hispidulum. The structure of these two compounds were elucidated by extensive spectra analysis including HR-ESI-MS, NMR (H-1, C-13, H-1-H-1 COSY, HSQC, and HMBC), CD, and electronic circular dichroism (ECD) combined with quantum-chemical calculations adopting time-dependent density functional theory (TDDFT) approaches. The W long-ranged H-1-H-1 COSY and HMBC correlations are very important in the structural elucidation of these two compounds. Hispidulone A (1) possesses a cyclohexa-2,5-dien-1-one moiety, whereas hispidulone B (2) contains a hemiacetal OCH3 group, which are very rare in the structures of phenalenone analogs. According to structural features of these two compounds together considering the literature, the possible biosynthetic pathway of 1 and 2 was postulated. Hispidulone B (2) displayed cytotoxic activities against three cancer cell lines A549, Huh7, and HeLa with IC50 values of 2.71 +/- 0.08, 22.93 +/- 1.61, and 23.94 +/- 0.33 mu M.
类型	Article
语种	英语
国家	Peoples R China
收录类别	SCI-E
WOS记录号	WOS:000524214900005
WOS关键词	DERIVATIVES
WOS类目	Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
WOS研究方向	Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/314859
作者单位	1.Chinese Acad Med Sci, Inst Med Plant Dev, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Beijing 100193, Peoples R China; 2.Peking Union Med Coll, Beijing 100193, Peoples R China; 3.Jilin Univ, Coll Plant Sci, Changchun 130062, Peoples R China; 4.Chinese Acad Sci, Inst Microbiol, Beijing 100090, Peoples R China; 5.Beijing City Univ, Sch Biol Med, Beijing 100083, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xiaoyan,Tan, Xiangmei,Li, Yuanyuan,et al. Hispidulones A and B, two new phenalenone analogs from desert plant endophytic fungus Chaetosphaeronema hispidulum[J],2020,73(1):56-59.
APA	Zhang, Xiaoyan.,Tan, Xiangmei.,Li, Yuanyuan.,Wang, Yanduo.,Yu, Meng.,...&Ding, Gang.(2020).Hispidulones A and B, two new phenalenone analogs from desert plant endophytic fungus Chaetosphaeronema hispidulum.JOURNAL OF ANTIBIOTICS,73(1),56-59.
MLA	Zhang, Xiaoyan,et al."Hispidulones A and B, two new phenalenone analogs from desert plant endophytic fungus Chaetosphaeronema hispidulum".JOURNAL OF ANTIBIOTICS 73.1(2020):56-59.