干旱区生态环境知识资源中心(Arid): Sledgehammer to Scalpel: Broad Challenges to the Heart and Other Tissues Yield Specific Cellular Responses via Transcriptional Regulation of the ER-Stress Master Regulator ATF6 alpha

Arid

DOI	10.3390/ijms21031134
	Sledgehammer to Scalpel: Broad Challenges to the Heart and Other Tissues Yield Specific Cellular Responses via Transcriptional Regulation of the ER-Stress Master Regulator ATF6 alpha
	Stauffer, Winston T.; Arrieta, Adrian; Blackwood, Erik A.; Glembotski, Christopher C.
通讯作者	Glembotski, Christopher C.
来源期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
EISSN	1422-0067
出版年	2020
卷号	21 期号:3
英文摘要	There are more than 2000 transcription factors in eukaryotes, many of which are subject to complex mechanisms fine-tuning their activity and their transcriptional programs to meet the vast array of conditions under which cells must adapt to thrive and survive. For example, conditions that impair protein folding in the endoplasmic reticulum (ER), sometimes called ER stress, elicit the relocation of the ER-transmembrane protein, activating transcription factor 6 alpha (ATF6 alpha), to the Golgi, where it is proteolytically cleaved. This generates a fragment of ATF6 alpha that translocates to the nucleus, where it regulates numerous genes that restore ER protein-folding capacity but is degraded soon after. Thus, upon ER stress, ATF6 alpha is converted from a stable, transmembrane protein, to a rapidly degraded, nuclear protein that is a potent transcription factor. This review focuses on the molecular mechanisms governing ATF6 alpha location, activity, and stability, as well as the transcriptional programs ATF6 alpha regulates, whether canonical genes that restore ER protein-folding or unexpected, non-canonical genes affecting cellular functions beyond the ER. Moreover, we will review fascinating roles for an ATF6 alpha isoform, ATF6 beta, which has a similar mode of activation but, unlike ATF6 alpha, is a long-lived, weak transcription factor that may moderate the genetic effects of ATF6 alpha
英文关键词	ATF6 alpha ATF6 beta ER stress transcriptional regulation proteostasis endoplasmic reticulum UPR OASIS basic leucine-zipper cardiac
类型	Review
语种	英语
国家	USA
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000522551608005
WOS关键词	UNFOLDED PROTEIN RESPONSE ; ENDOPLASMIC-RETICULUM ; ACTIVATING TRANSCRIPTION ; DISULFIDE BRIDGES ; GENE-EXPRESSION ; LUMINAL DOMAIN ; NF-Y ; ATF6 ; BINDING ; DEGRADATION
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/314779
作者单位	San Diego State Univ, Dept Biol, Heart Inst, San Diego, CA 92182 USA
推荐引用方式 GB/T 7714	Stauffer, Winston T.,Arrieta, Adrian,Blackwood, Erik A.,et al. Sledgehammer to Scalpel: Broad Challenges to the Heart and Other Tissues Yield Specific Cellular Responses via Transcriptional Regulation of the ER-Stress Master Regulator ATF6 alpha[J],2020,21(3).
APA	Stauffer, Winston T.,Arrieta, Adrian,Blackwood, Erik A.,&Glembotski, Christopher C..(2020).Sledgehammer to Scalpel: Broad Challenges to the Heart and Other Tissues Yield Specific Cellular Responses via Transcriptional Regulation of the ER-Stress Master Regulator ATF6 alpha.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,21(3).
MLA	Stauffer, Winston T.,et al."Sledgehammer to Scalpel: Broad Challenges to the Heart and Other Tissues Yield Specific Cellular Responses via Transcriptional Regulation of the ER-Stress Master Regulator ATF6 alpha".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21.3(2020).