干旱区生态环境知识资源中心(Arid): Screening of drought-resistance related genes and analysis of promising regulatory pathway in camel renal medulla

Arid

DOI	10.1016/j.ygeno.2020.02.014
	Screening of drought-resistance related genes and analysis of promising regulatory pathway in camel renal medulla
	Zhang, Dong 1; Pan, Jing 1; Cao, Junwei 1; Cao, Yu 1,2; Zhou, Huanmin 1
通讯作者	Cao, Yu ; Zhou, Huanmin
来源期刊	GENOMICS
ISSN	0888-7543
EISSN	1089-8646
出版年	2020
卷号	112 期号:3 页码:2633-2639
英文摘要	Camels as a sort of animal long living in desert have evolved stress-resistance characteristics to adapt to environment with high temperature and water shortage environment. However, the research of non-coding RNA (ncRNA)-mediated molecular regulation about how camel responds to arid condition in post-transcriptional regulation level is deficient. Under water-deprivation stress, by RNA-sequencing of camel renal medulla associated with regulating water metabolism, we detected significantly differential 575 alternative splicing events (ASEs) and 17 mRNAs, 26 miRNAs and 0 lncRNA. The down-regulated ACLY and LOC105061856, up-regulated PCBP2 and miR-195 potentially targeting LOC105061856 and PCBP2 mRNA were selected as candidate resistance-related genes. In quantitative experiment, the expression level of above four genes was consistent with RNA-seq data by qRT-PCR. The suppressive cell dehydration with down-regulated ACLY, inhibitive aerobic respiration with down-regulated LOC105061856 targeted by miR-195 and strong anti-oxidative capability with PCBP2 aimed by miR-195 may be regulatory modes of camel renal medulla adapting to water-deprivation condition.
英文关键词	Camel Non-coding RNA Post-transcriptional regulation Water-deprivation stress Renal medulla
类型	Article
语种	英语
国家	Peoples R China
开放获取类型	Bronze
收录类别	SCI-E
WOS记录号	WOS:000519997800057
WOS关键词	ATP-CITRATE LYASE ; HEAT-SHOCK ; EXPRESSION ; DROMEDARIUS ; TRANSLATION ; TRANSCRIPTS ; ACTIVATION ; CLONING
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/314575
作者单位	1.Inner Mongolia Agr Univ, Coll Life Sci, 306 Zhaowuda Rd, Hohhot 010018, Peoples R China; 2.Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, 10 Poyanghu Rd, Tianjin 301617, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Dong,Pan, Jing,Cao, Junwei,et al. Screening of drought-resistance related genes and analysis of promising regulatory pathway in camel renal medulla[J],2020,112(3):2633-2639.
APA	Zhang, Dong,Pan, Jing,Cao, Junwei,Cao, Yu,&Zhou, Huanmin.(2020).Screening of drought-resistance related genes and analysis of promising regulatory pathway in camel renal medulla.GENOMICS,112(3),2633-2639.
MLA	Zhang, Dong,et al."Screening of drought-resistance related genes and analysis of promising regulatory pathway in camel renal medulla".GENOMICS 112.3(2020):2633-2639.