干旱区生态环境知识资源中心(Arid): Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic Diseases

Arid

DOI	10.3389/fphar.2020.00151
	Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic Diseases
	Manda, Gina 1; Rojo, Ana I.2; Martinez-Klimova, Elena 3; Pedraza-Chaverri, Jose 3; Cuadrado, Antonio 1,2
通讯作者	Cuadrado, Antonio
来源期刊	FRONTIERS IN PHARMACOLOGY
ISSN	1663-9812
出版年	2020
卷号	11
英文摘要	Nordihydroguaiaretic acid (NDGA) is a phenolic lignan obtained from Larrea tridentata, the creosote bush found in Mexico and USA deserts, that has been used in traditional medicine for the treatment of numerous diseases such as cancer, renal, cardiovascular, immunological, and neurological disorders, and even aging. NDGA presents two catechol rings that confer a very potent antioxidant activity by scavenging oxygen free radicals and this may explain part of its therapeutic action. Additional effects include inhibition of lipoxygenases (LOXs) and activation of signaling pathways that impinge on the transcription factor Nuclear Factor Erythroid 2-related Factor (NRF2). On the other hand, the oxidation of the catechols to the corresponding quinones my elicit alterations in proteins and DNA that raise safety concerns. This review describes the current knowledge on NDGA, its targets and side effects, and its synthetic analogs as promising therapeutic agents, highlighting their mechanism of action and clinical projection towards therapy of neurodegenerative, liver, and kidney disease, as well as cancer.
英文关键词	catechol quinone electrophiles NRF2 KEAP1 cytoprotection oxidative stress inflammation
类型	Review
语种	英语
国家	Romania ; Spain ; Mexico
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000525526400001
WOS关键词	TRANSCRIPTION FACTOR NRF2 ; ACTIVATED PROTEIN-KINASE ; TRIDENTATA CREOSOTE BUSH ; CUL3-BASED E3 LIGASE ; OXIDATIVE STRESS ; IN-VIVO ; INDUCED APOPTOSIS ; BREAST-CANCER ; PHASE-I ; FUNCTIONAL-CHARACTERIZATION
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
来源机构	Universidad Nacional Autónoma de México
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/314556
作者单位	1.Victor Babes Natl Inst Pathol, Dept Cellular & Mol Med, Bucharest, Romania; 2.Autonomous Univ Madrid, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Inst Invest Sanitaria Paz IdiPAZ, Dept Biochem,Fac Med,Inst Invest Biomed Alberto S, Madrid, Spain; 3.Natl Autonomous Univ Mexico UNAM, Dept Biol, Fac Chem, Mexico City, DF, Mexico
推荐引用方式 GB/T 7714	Manda, Gina,Rojo, Ana I.,Martinez-Klimova, Elena,et al. Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic Diseases[J]. Universidad Nacional Autónoma de México,2020,11.
APA	Manda, Gina,Rojo, Ana I.,Martinez-Klimova, Elena,Pedraza-Chaverri, Jose,&Cuadrado, Antonio.(2020).Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic Diseases.FRONTIERS IN PHARMACOLOGY,11.
MLA	Manda, Gina,et al."Nordihydroguaiaretic Acid: From Herbal Medicine to Clinical Development for Cancer and Chronic Diseases".FRONTIERS IN PHARMACOLOGY 11(2020).