干旱区生态环境知识资源中心(Arid): Exposure to radioactive rocks from the Egyptian eastern desert attenuates the efficiency of the immune organs and induces apoptosis of blood lymphocytes in rat model

Arid

DOI	10.1007/s11356-019-07572-y
	Exposure to radioactive rocks from the Egyptian eastern desert attenuates the efficiency of the immune organs and induces apoptosis of blood lymphocytes in rat model
	Badr, Gamal 1,2; El-Reda, Ghada Abd 3; El-Gamal, Hany 3; Farid, Mohamed El-Azab 3
通讯作者	Badr, Gamal
来源期刊	ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
ISSN	0944-1344
EISSN	1614-7499
出版年	2020
卷号	27 期号:8 页码:8684-8695
英文摘要	Exposure to ionizing radiation emitted from natural sources induces many health hazards. The response to ionizing radiation involves a number of mediators including inflammatory cytokines and free radicals which mediate immunosuppression. The present study aimed to monitor the impact of exposure to natural radioactive rocks from the Egyptian eastern desert on the primary immune organs. Therefore, three experimental groups (15 rats per group) were used: group I included the control non-irradiated rats; group II included rats that were exposed for 28 consecutive days to natural radioactive rocks from the Egyptian eastern desert (IR/R group); and group III (positive control group) included rats that were exposed to high dose of gamma-rays (4 Gy/14 days for 28 days) (IR/gamma R group). We found that rats of both the IR/R and IR/gamma R groups exhibited pathological alterations in the architecture of the primary immune organs (bone marrow and thymus). Additionally, the levels of C-reactive protein (CRP), proinflammatory cytokines (IL-1 beta, IL-6 and TNF-alpha), and reactive oxygen species (ROS) were significantly increased in the IR/R and IR/gamma R groups compared to the control group. Furthermore, rats from the IR/R and IR/gamma R groups exhibited significant increase in the activity of caspase-3 and caspase-9 and subsequently exhibited a significant increase in the apoptosis of PBMCs compared with the control group. Most importantly, apoptosis induction in the PBMCs was associated with increased expression of cyclin B1 and decreased expression of cyclin D1 and survivin compared with the control non-irradiated group. Taken together, our data demonstrated that consecutive exposure to natural radioactive rocks from the Egyptian eastern desert could dampen the immune response through damaging the architectures of the immune system and mediating serious health problems to the population inhabiting this region.
英文关键词	Apoptosis Cyclin Inflammation Radiation ROS Survivin
类型	Article
语种	英语
国家	Egypt
收录类别	SCI-E
WOS记录号	WOS:000517084600078
WOS关键词	IONIZING-RADIATION ; GAMMA-IRRADIATION ; DAMAGE ; MECHANISMS ; IDENTIFICATION ; MELATONIN ; SURVIVIN ; CYTOKINE ; GROWTH
WOS类目	Environmental Sciences
WOS研究方向	Environmental Sciences & Ecology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/314461
作者单位	1.Assiut Univ, Fac Sci, Zool Dept, Assiut 71516, Egypt; 2.Assiut Univ, Fac Sci, Zool Dept, Lab Immunol, Assiut 71516, Egypt; 3.Assiut Univ, Fac Sci, Dept Phys, Assiut 71516, Egypt
推荐引用方式 GB/T 7714	Badr, Gamal,El-Reda, Ghada Abd,El-Gamal, Hany,et al. Exposure to radioactive rocks from the Egyptian eastern desert attenuates the efficiency of the immune organs and induces apoptosis of blood lymphocytes in rat model[J],2020,27(8):8684-8695.
APA	Badr, Gamal,El-Reda, Ghada Abd,El-Gamal, Hany,&Farid, Mohamed El-Azab.(2020).Exposure to radioactive rocks from the Egyptian eastern desert attenuates the efficiency of the immune organs and induces apoptosis of blood lymphocytes in rat model.ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,27(8),8684-8695.
MLA	Badr, Gamal,et al."Exposure to radioactive rocks from the Egyptian eastern desert attenuates the efficiency of the immune organs and induces apoptosis of blood lymphocytes in rat model".ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 27.8(2020):8684-8695.