干旱区生态环境知识资源中心(Arid): Stem Leydig Cells in the Adult Testis: Characterization, Regulation and Potential Applications

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DOI	10.1210/endrev/bnz013
	Stem Leydig Cells in the Adult Testis: Characterization, Regulation and Potential Applications
	Chen, Panpan 1,2; Zirkin, Barry R.3; Chen, Haolin 1,2,4
通讯作者	Zirkin, Barry R. ; Chen, Haolin
来源期刊	ENDOCRINE REVIEWS
ISSN	0163-769X
EISSN	1945-7189
出版年	2020
卷号	41 期号:1 页码:22-32
英文摘要	Androgen deficiency (hypogonadism) affects males of all ages. Testosterone replacement therapy (TRT) is effective in restoring serum testosterone and relieving symptoms. TRT, however, is reported to have possible adverse effects in part because administered testosterone is not produced in response to the hypothalamic-pituitary-gonadal (HPG) axis. Progress in stem cell biology offers potential alternatives for treating hypogonadism. Adult Leydig cells (ALCs) are generated by stem Leydig cells (SLCs) during puberty. SLCs persist in the adult testis. Considerable progress has been made in the identification, isolation, expansion and differentiation of SLCs in vitro. In addition to forming ALCs, SLCs are multi potent, with the ability to give rise to all 3 major cell lineages of typical mesenchymal stem cells, including osteoblasts, adipocytes, and chondrocytes. Several regulatory factors, including Desert hedgehog and platelet-derived growth factor, have been reported to play key roles in the proliferation and differentiation of SLCs into the Leydig lineage. In addition, stem cells from several nonsteroidogenic sources, including embryonic stem cells, induced pluripotent stem cells, mature fibroblasts, and mesenchymal stem cells from bone marrow, adipose tissue, and umbilical cord have been transdifferentiated into Leydig-like cells under a variety of induction protocols. ALCs generated from SLCs in vitro, as well as Leydig-like cells, have been successfully transplanted into ALC-depleted animals, restoring serum testosterone levels under HPG control. However, important questions remain, including: How long will the transplanted cells continue to function? Which induction protocol is safest and most effective? For translational purposes, more work is needed with primate cells, especially human. [GRAPHICS] .
英文关键词	stem Leydig cells steroidogenic stem cells transdifferentiation testosterone hypogonadism transplantation
类型	Review
语种	英语
国家	Peoples R China ; USA
开放获取类型	Green Published, Bronze
收录类别	SCI-E
WOS记录号	WOS:000518162200002
WOS关键词	AMELIORATE TESTICULAR DYSFUNCTION ; STEROIDOGENIC FACTOR-I ; MESENCHYMAL CELLS ; NUCLEAR RECEPTOR ; TESTOSTERONE ; DIFFERENTIATION ; HYPOGONADISM ; FETAL ; FIBROBLASTS ; EXPRESSION
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/314388
作者单位	1.Wenzhou Med Univ, Dept Gynecol & Obstet, Affiliated Hosp 2, Bldg 11-713,109 Xue Yuan Dong Lu, Wenzhou 325027, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Yuying Childrens Hosp, Bldg 11-713,109 Xue Yuan Dong Lu, Wenzhou 325027, Zhejiang, Peoples R China; 3.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biochem & Mol Biol, Baltimore, MD 21205 USA; 4.Wenzhou Med Univ, Dept Anesthesiol Perioperat Med, Zhejiang Prov Key Lab Anesthesiol, Affiliated Hosp 2, Wenzhou 325027, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Chen, Panpan,Zirkin, Barry R.,Chen, Haolin. Stem Leydig Cells in the Adult Testis: Characterization, Regulation and Potential Applications[J],2020,41(1):22-32.
APA	Chen, Panpan,Zirkin, Barry R.,&Chen, Haolin.(2020).Stem Leydig Cells in the Adult Testis: Characterization, Regulation and Potential Applications.ENDOCRINE REVIEWS,41(1),22-32.
MLA	Chen, Panpan,et al."Stem Leydig Cells in the Adult Testis: Characterization, Regulation and Potential Applications".ENDOCRINE REVIEWS 41.1(2020):22-32.