干旱区生态环境知识资源中心(Arid): Melanin biosynthesis in the desert-derived Aureobasidium melanogenum XJ5-1 is controlled mainly by the CWI signal pathway via a transcriptional activator Cmr1

Arid

DOI	10.1007/s00294-019-01010-9
	Melanin biosynthesis in the desert-derived Aureobasidium melanogenum XJ5-1 is controlled mainly by the CWI signal pathway via a transcriptional activator Cmr1
	Jiang, Hong 1; Chi, Zhe 1,2; Liu, Guang-Lei 1,2; Hu, Zhong 3; Zhao, Shuang-Zhi 4; Chi, Zhen-Ming 1,2
通讯作者	Chi, Zhen-Ming
来源期刊	CURRENT GENETICS
ISSN	0172-8083
EISSN	1432-0983
出版年	2020
卷号	66 期号:1 页码:173-185
英文摘要	The melanin produced by Aureobasidium melanogenum XJ5-1 obtained from the Taklimakan Desert can play an important role in adaptation of the yeast strain to various stress treatments. It is very important to know how the desert-derived yeast sense, respond and adapt to the harsh environments. However, it is still unclear how melanin is genetically controlled by signaling pathways and transcriptional factors. In this study, it was found that the mitogen-activated protein kinase (MAPK) Slt2 in the cell wall integrity (CWI) signal pathway could regulate activity of the transcriptional activator Swi4; in turn, the Swi4 could control the expression of the CMR1 gene. The melanin-specific transcriptional activator Cmr1 encoded by the CMR1 gene was specifically bound to the promoter with the sequence TTCTCTCCA of the PKS1 gene and strongly stimulated expression of the PKS1 gene and any other genes responsible for melanin biosynthesis, so that a large amount of melanin could be produced by A. melanogenum XJ5-1. Therefore, melanin biosynthesis in the desert-derived A. melanogenum XJ5-1 was controlled mainly by the CWI signal pathway among the cell wall-related signal pathways via a transcriptional activator Cmr and regulation of the melanin biosynthesis in A. melanogenum XJ5-1 was completely different from that of the melanin biosynthesis in any other fungi. This is the first time to show that melanin biosynthesis in the desert-derived A. melanogenum XJ5-1 is controlled mainly by the CWI signal pathway via a transcriptional activator Cmr1. This would provide the fundamentals for further research on the desert-derived yeast to sense, respond and adapt to the harsh environments.
英文关键词	Taklimakan desert Harsh environment A melanogenum Transcriptional activator Melanin biosynthesis
类型	Article
语种	英语
国家	Peoples R China
收录类别	SCI-E
WOS记录号	WOS:000513356600015
WOS关键词	PULLULAN BIOSYNTHESIS ; TAKLIMAKAN DESERT ; STRESS RESPONSES ; STRAIN ; GENES ; YEAST ; SENSITIVITY ; VIRULENCE ; PROTEINS
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/314297
作者单位	1.Ocean Univ China, Dept Biol, Coll Marine Life Sci, Yushan Rd 5, Qingdao, Peoples R China; 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266003, Peoples R China; 3.Shantou Univ, Dept Biol, Shantou 515063, Peoples R China; 4.Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Jinan 250100, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Hong,Chi, Zhe,Liu, Guang-Lei,et al. Melanin biosynthesis in the desert-derived Aureobasidium melanogenum XJ5-1 is controlled mainly by the CWI signal pathway via a transcriptional activator Cmr1[J],2020,66(1):173-185.
APA	Jiang, Hong,Chi, Zhe,Liu, Guang-Lei,Hu, Zhong,Zhao, Shuang-Zhi,&Chi, Zhen-Ming.(2020).Melanin biosynthesis in the desert-derived Aureobasidium melanogenum XJ5-1 is controlled mainly by the CWI signal pathway via a transcriptional activator Cmr1.CURRENT GENETICS,66(1),173-185.
MLA	Jiang, Hong,et al."Melanin biosynthesis in the desert-derived Aureobasidium melanogenum XJ5-1 is controlled mainly by the CWI signal pathway via a transcriptional activator Cmr1".CURRENT GENETICS 66.1(2020):173-185.