干旱区生态环境知识资源中心(Arid): Biosynthesis, Characterization, and Evaluation of the Cytotoxic Effects of Biologically Synthesized Silver Nanoparticles from Cyperus conglomeratus Root Extracts on Breast Cancer Cell Line MCF-7

Arid

DOI	10.1007/s12011-019-01791-7
	Biosynthesis, Characterization, and Evaluation of the Cytotoxic Effects of Biologically Synthesized Silver Nanoparticles from Cyperus conglomeratus Root Extracts on Breast Cancer Cell Line MCF-7
	Al-Nuairi, Amani Ghassan 1; Mosa, Kareem A.1,2; Mohammad, Mohammad G.3,4; El-Keblawy, Ali 1; Soliman, Sameh 5,6; Alawadhi, Hussain 7
通讯作者	Mosa, Kareem A.
来源期刊	BIOLOGICAL TRACE ELEMENT RESEARCH
ISSN	0163-4984
EISSN	1559-0720
出版年	2020
卷号	194 期号:2 页码:560-569
英文摘要	Over recent years, metal nanoparticles have largely been investigated due to their potential activities. This study focused on synthesizing silver nanoparticles (AgNPs) using the desert plant Cyperus conglomeratus, which is the most abundant species on the sand dunes in the UAE, and their anticancer activity. The synthesized AgNPs were characterized using UV-visible spectra, X-ray diffraction, energy dispersive X-ray spectroscopy, fourier transform infrared spectroscopy, dynamic light scattering, and scanning electron microscope. The results showed that the AgNPs are monodispersed and mostly spherical in shape. The cytotoxicity effects were investigated against breast cancer cells MCF-7 and normal fibroblast using MTT assay which showed selective cytotoxicity against MCF-7 with an IC50 at 5 mu g/mL but not fibroblast. Moreover, the apoptotic effects were confirmed using annexin V-FITC-PI double staining kit and real-time PCR for apoptotic genes. Therefore, our results revealed potential anticancer applications of the C. conglomeratus biosynthesized silver nanoparticles.
英文关键词	C conglomeratus Silver nanoparticles Anticancer Apoptosis
类型	Article
语种	英语
国家	U Arab Emirates ; Egypt
收录类别	SCI-E
WOS记录号	WOS:000512987500027
WOS关键词	GREEN SYNTHESIS ; ANTIBACTERIAL ACTIVITY ; ANTICANCER ACTIVITY ; BETA-SITOSTEROL ; AQUEOUS EXTRACT ; APOPTOSIS ; AU ; AG
WOS类目	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/314185
作者单位	1.Univ Sharjah, Coll Sci, Dept Appl Biol, Sharjah, U Arab Emirates; 2.Al Azhar Univ, Fac Agr, Dept Biotechnol, Cairo, Egypt; 3.Univ Sharjah, Dept Med Lab Sci, Coll Hlth Sci, Sharjah, U Arab Emirates; 4.Univ Sharjah, Sharjah Inst Med Res, Iron Biol Res Grp, Sharjah, U Arab Emirates; 5.Univ Sharjah, Coll Pharm, Sharjah, U Arab Emirates; 6.Univ Sharjah, Sharjah Inst Med Res, Infectous Dis Res Grp, Sharjah, U Arab Emirates; 7.Univ Sharjah, Ctr Adv Mat Res, Res Inst Sci & Engn, Sharjah, U Arab Emirates
推荐引用方式 GB/T 7714	Al-Nuairi, Amani Ghassan,Mosa, Kareem A.,Mohammad, Mohammad G.,et al. Biosynthesis, Characterization, and Evaluation of the Cytotoxic Effects of Biologically Synthesized Silver Nanoparticles from Cyperus conglomeratus Root Extracts on Breast Cancer Cell Line MCF-7[J],2020,194(2):560-569.
APA	Al-Nuairi, Amani Ghassan,Mosa, Kareem A.,Mohammad, Mohammad G.,El-Keblawy, Ali,Soliman, Sameh,&Alawadhi, Hussain.(2020).Biosynthesis, Characterization, and Evaluation of the Cytotoxic Effects of Biologically Synthesized Silver Nanoparticles from Cyperus conglomeratus Root Extracts on Breast Cancer Cell Line MCF-7.BIOLOGICAL TRACE ELEMENT RESEARCH,194(2),560-569.
MLA	Al-Nuairi, Amani Ghassan,et al."Biosynthesis, Characterization, and Evaluation of the Cytotoxic Effects of Biologically Synthesized Silver Nanoparticles from Cyperus conglomeratus Root Extracts on Breast Cancer Cell Line MCF-7".BIOLOGICAL TRACE ELEMENT RESEARCH 194.2(2020):560-569.