干旱区生态环境知识资源中心(Arid): A Genome-Wide Association Study Identifies Quantitative Trait Loci Affecting Hematological Traits in Camelus bactrianus

Arid

DOI	10.3390/ani10010096
	A Genome-Wide Association Study Identifies Quantitative Trait Loci Affecting Hematological Traits in Camelus bactrianus
	Guo, Fucheng 1; Ming, Liang 1; Si, Rendalai 1,2; Yi, Li 1; He, Jing 1; Ji, Rimutu 1,2
通讯作者	Ji, Rimutu
来源期刊	ANIMALS
ISSN	2076-2615
出版年	2020
卷号	10 期号:1
英文摘要	Simple Summary Bactrian camels can adapt to harsh natural environments. This unique tolerance of camels is tightly linked to their hematological traits, which are related to their immune, metabolic, and disease status. Therefore, mapping genomic regions that affect blood cell traits can help identify genomic characteristics that can be used as biomarkers of immune, metabolic, and disease states. This knowledge will further our understanding of the camel's tolerance mechanisms. Abstract Bactrian camels (Camelus bactrianus) are one of the few large livestock species that can survive in the Gobi Desert. Animal immunity and disease resistance are related to hematological traits, which are also associated with tolerance observed in Bactrian camels. However, no genome-wide association studies have examined the genetic mechanism of the immune capability of Bactrian camels. In the present study, we used genotyping-by-sequencing data generated from 366 Bactrian camel accessions to perform a genome-wide association study for 17 hematological traits. Of the 256,616 single-nucleotide polymorphisms (SNPs) obtained, 1,635 trait-SNP associations were among the top quantitative trait locus candidates. Lastly, 664 candidate genes associated with 13 blood traits were identified. The most significant were ZNF772, MTX2, ESRRG, MEI4, IL11, FRMPD4, GABPA, NTF4, CRYBG3, ENPP5, COL16A1, and CD207. The results of our genome-wide association study provide a list of significant SNPs and candidate genes, which offer valuable information for further dissection of the molecular mechanisms that regulate the camel's hematological traits to ultimately reveal their tolerance mechanisms.
英文关键词	Camelus bactrianus hematological traits genome-wide association studies loci
类型	Article
语种	英语
国家	Peoples R China
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000515364400096
WOS关键词	GENE ; ORIGIN
WOS类目	Agriculture, Dairy & Animal Science ; Veterinary Sciences
WOS研究方向	Agriculture ; Veterinary Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/314022
作者单位	1.Inner Mongolia Agr Univ, Coll Food Sci & Engn, Minist Educ, Key Lab Dairy Biotechnol & Bioengn, Hohhot 010018, Peoples R China; 2.Camel Res Inst Inner Mongolia, Alxa 737300, Peoples R China
推荐引用方式 GB/T 7714	Guo, Fucheng,Ming, Liang,Si, Rendalai,et al. A Genome-Wide Association Study Identifies Quantitative Trait Loci Affecting Hematological Traits in Camelus bactrianus[J],2020,10(1).
APA	Guo, Fucheng,Ming, Liang,Si, Rendalai,Yi, Li,He, Jing,&Ji, Rimutu.(2020).A Genome-Wide Association Study Identifies Quantitative Trait Loci Affecting Hematological Traits in Camelus bactrianus.ANIMALS,10(1).
MLA	Guo, Fucheng,et al."A Genome-Wide Association Study Identifies Quantitative Trait Loci Affecting Hematological Traits in Camelus bactrianus".ANIMALS 10.1(2020).