干旱区生态环境知识资源中心(Arid): Inhibition of Immunosuppressive Tumors by Polymer-Assisted Inductions of Immunogenic Cell Death and Multivalent PD-L1 Crosslinking

Arid

DOI	10.1002/adfm.201908961
	Inhibition of Immunosuppressive Tumors by Polymer-Assisted Inductions of Immunogenic Cell Death and Multivalent PD-L1 Crosslinking
	Li, Lian 1; Li, Yachao 1; Yang, Chieh-Hsiang 2; Radford, Christopher 2; Wang, Jiawei 1; Janat-Amsbury, Margit 1; Kopecek, Jindrich 1,2; Yang, Jiyuan 1
通讯作者	Kopecek, Jindrich ; Yang, Jiyuan
来源期刊	ADVANCED FUNCTIONAL MATERIALS
ISSN	1616-301X
EISSN	1616-3028
出版年	2020
卷号	30 期号:12
英文摘要	Checkpoint blockade immunotherapies harness the host's own immune system to fight cancer, but only work against tumors infiltrated by swarms of preexisting T cells. Unfortunately, most cancers to date are immune-deserted. Here, a polymer-assisted combination of immunogenic chemotherapy and PD-L1 degradation is reported for efficacious treatment in originally nonimmunogenic cancer. Priming tumors with backbone-degradable polymer-epirubicin conjugates elicits immunogenic cell death and fosters tumor-specific CD8+ T cell response. Sequential treatment with a multivalent polymer-peptide antagonist to PD-L1 overcomes adaptive PD-L1 enrichment following chemotherapy, biases the recycling of PD-L1 to lysosome degradation via surface receptor crosslinking, and produces prolonged elimination of PD-L1 rather than the transient blocking afforded by standard anti-PD-L1 antibodies. Together, these findings establish the polymer-facilitated tumor targeting of immunogenic drugs and surface crosslinking of PD-L1 as a potential new therapeutic strategy to propagate long-term antitumor immunity, which might broaden the application of immunotherapy to immunosuppressive cancers.
英文关键词	checkpoint blockade immunotherapy HPMA polymer immunogenic cell death immunosuppressive tumor PD-L1 crosslinking
类型	Article
语种	英语
国家	USA
开放获取类型	hybrid, Green Accepted
收录类别	SCI-E
WOS记录号	WOS:000510470500001
WOS关键词	ANTICANCER CHEMOTHERAPY ; CHECKPOINT BLOCKADE ; CANCER ; EXPRESSION ; THERAPY ; SYSTEM
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
EI主题词	2020-02-03
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/312803
作者单位	1.Univ Utah, Ctr Controlled Chem Delivery, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USA; 2.Univ Utah, Dept Biomed Engn, Salt Lake City, UT 84112 USA
推荐引用方式 GB/T 7714	Li, Lian,Li, Yachao,Yang, Chieh-Hsiang,et al. Inhibition of Immunosuppressive Tumors by Polymer-Assisted Inductions of Immunogenic Cell Death and Multivalent PD-L1 Crosslinking[J],2020,30(12).
APA	Li, Lian.,Li, Yachao.,Yang, Chieh-Hsiang.,Radford, Christopher.,Wang, Jiawei.,...&Yang, Jiyuan.(2020).Inhibition of Immunosuppressive Tumors by Polymer-Assisted Inductions of Immunogenic Cell Death and Multivalent PD-L1 Crosslinking.ADVANCED FUNCTIONAL MATERIALS,30(12).
MLA	Li, Lian,et al."Inhibition of Immunosuppressive Tumors by Polymer-Assisted Inductions of Immunogenic Cell Death and Multivalent PD-L1 Crosslinking".ADVANCED FUNCTIONAL MATERIALS 30.12(2020).