干旱区生态环境知识资源中心(Arid): Prognostic relevance of pre- and postoperative plasma L-lactate measurements in calves with acute abdominal emergencies

Arid

DOI	10.3168/jds.2019-17224
	Prognostic relevance of pre- and postoperative plasma L-lactate measurements in calves with acute abdominal emergencies
	Lausch, C. K.1; Lorch, A.1; Giertzuch, S.1; Rieger, A.1; Knubben-Schweizer, G.1; Trefz, F. M.1,2
通讯作者	Trefz, F. M.
来源期刊	JOURNAL OF DAIRY SCIENCE
ISSN	0022-0302
EISSN	1525-3198
出版年	2020
卷号	103 期号:2 页码:1856-1865
英文摘要	In both human and veterinary medicine, L-lactate is a well-established prognostic biomarker of disease severity and mortality and has also attracted increasing attention in bovine medicine due to the availability and validation of cheap and portable ',lactate analyzers. The aim of the present study was to evaluate the prognostic accuracy of plasma L-lactate measurements in calves with acute abdominal emergencies before and during the initial therapeutic period after surgical intervention. A prospective observational study was carried out involving 83 hospitalized calves up to an age of 7 mo, which required surgical intervention for reasons of an acute abdominal emergency such as gastrointestinal ileus or peritonitis. Plasma ',lactate (L-LAC) concentrations were determined immediately before initiation of surgery and 6, 12, 24, 48, and 72 h later. The outcome of calves was evaluated 3 mo after discharge by a phone call to the farmer, and a positive outcome was defined if the calf was still alive and the owner was satisfied with the animal's postsurgical progress. A total of 29% of calves were discharged from the hospital arid the proportion of calves with a positive outcome after the 3-mo period was 24%. At all sampling times during the first 48 h after initiation of surgical intervention, calves with a negative outcome had significantly higher L-LAC than calves with a positive outcome. A binary logistic regression analysis indicated that the odds for a negative outcome during the 3-mo observation period increased by a factor of 1.23 [95% confidence interval (CI): 1.04-1.44] for every mmol/L increase of L-LAC before initiation of surgical intervention, but by a factor of 5.29 (95% CI: 1.69-16.6) and 5.92 (95% CI: 1.29-27.3) at 12 and 24 h, respectively. The largest area under the receiver operating characteristic curve for L-LAC was observed at 12 h (0.91; 95% CI: 0.83-0.99), and a cut-point of 2.75 mmol/L was identified that had a sensitivity and specificity for predicting a negative outcome of 68 and 100%, respectively. In conclusion, persistent hyper-L-lactatemia during the early postoperative period is a more reliable indicator for a negative outcome in calves with acute surgical abdominal emergencies than hyper-L-lactatemia before initiation of surgical intervention. Postoperative measurements of L-LAC are therefore a clinically useful tool to identify patients with an increased risk for a negative outcome at an early stage after surgical intervention was carried out.
英文关键词	calf ileus peritonitis hyper-L-lactatemia surgical abdominal emergency
类型	Article
语种	英语
国家	Germany ; Switzerland
开放获取类型	Bronze
收录类别	SCI-E
WOS记录号	WOS:000507480100067
WOS关键词	GASTRIC DILATATION-VOLVULUS ; HOLSTEIN DAIRY-CATTLE ; LACTIC-ACIDOSIS ; CLINICAL-USE ; COW-SIDE ; SURVIVAL ; ABOMASAL ; ASSOCIATION ; CLEARANCE ; PREDICTOR
WOS类目	Agriculture, Dairy & Animal Science ; Food Science & Technology
WOS研究方向	Agriculture ; Food Science & Technology
EI主题词	2020-02-01
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/312651
作者单位	1.Ludwig Maximilians Univ LMU Munich, Ctr Clin Vet Med, Clin Ruminants Ambulatory & Herd Hlth Serv, Sonnenstr 16, D-85764 Oberschleissheim, Germany; 2.Univ Bern, Vetsuisse Fac, Clin Ruminants, Bremgartenstr 109a, CH-3012 Bern, Switzerland
推荐引用方式 GB/T 7714	Lausch, C. K.,Lorch, A.,Giertzuch, S.,et al. Prognostic relevance of pre- and postoperative plasma L-lactate measurements in calves with acute abdominal emergencies[J],2020,103(2):1856-1865.
APA	Lausch, C. K.,Lorch, A.,Giertzuch, S.,Rieger, A.,Knubben-Schweizer, G.,&Trefz, F. M..(2020).Prognostic relevance of pre- and postoperative plasma L-lactate measurements in calves with acute abdominal emergencies.JOURNAL OF DAIRY SCIENCE,103(2),1856-1865.
MLA	Lausch, C. K.,et al."Prognostic relevance of pre- and postoperative plasma L-lactate measurements in calves with acute abdominal emergencies".JOURNAL OF DAIRY SCIENCE 103.2(2020):1856-1865.