干旱区生态环境知识资源中心(Arid): Humulene Diepoxides from the Australian Arid Zone Herb Dysphania: Assignment of Aged Hops Constituents

Arid

DOI	10.1002/chem.201904420
	Humulene Diepoxides from the Australian Arid Zone Herb Dysphania: Assignment of Aged Hops Constituents
	Tan, Yuen Ping 1; Agnew-Francis, Kylie A.1; Hofmann, Julian 2; Savchenko, Andrei, I 1; Lafontaine, Scott R.3; Boyle, Glen M.4; Bernhardt, Paul, V 1; Fraser, James A.1; Shellhammer, Thomas H.3; Williams, Craig M.1
通讯作者	Williams, Craig M.
来源期刊	CHEMISTRY-A EUROPEAN JOURNAL
ISSN	0947-6539
EISSN	1521-3765
出版年	2020
卷号	26 期号:7 页码:1653-1660
英文摘要	Dysphania is an abundant genus of plants, many of which are endemic to the Australian continent, occurring primarily in arid and temperate zones. Despite their prevalence, very few investigations into the phytochemistry of native Dysphania have been undertaken. Described herein, is the isolation and elucidation of two enantiomeric diastereomers of humulene diepoxide C from D. kalpari and D. rhadinostachya, of which unassigned diastereomers of humulene diepoxide C have been previously reported as components in beer brewed from aged hops. In addition, two (+)-humulene diepoxiols (humulene diepoxiol C-I and C-II) were isolated from D. rhadinostachya. Analysis of Chinook hops oil confirmed the presence of both humulene diepoxide C-I and C-II as trace components, and in turn enabled GC-MS peak assignment to the relative stereochemistry. Anticancer assays did not reveal any significant activity for the (+)-humulene diepoxides. Antifungal assays showed good activity against a drug-resistant strain of C. auris, with MIC50 values of 8.53 and 4.91 mu m obtained for (+)-humulene diepoxide C-I and C-II, respectively.
英文关键词	diepoxides epoxides hops humulenes natural products
类型	Article
语种	英语
国家	Australia ; Germany ; USA
开放获取类型	Bronze
收录类别	SCI-E
WOS记录号	WOS:000508226800001
WOS关键词	SESQUITERPENES ; CONFORMATION ; CHEMISTRY ; PLANTS ; AROMA
WOS类目	Chemistry, Multidisciplinary
WOS研究方向	Chemistry
EI主题词	2020-01-21
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/312562
作者单位	1.Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia; 2.Karlsruhe Inst Technol, Inst Organ Chem, D-76131 Karlsruhe, Germany; 3.Oregon State Univ, Dept Food Sci & Technol, Corvallis, OR 97331 USA; 4.PO Royal Brisbane Hosp, QIMR Berghofer Med Res Inst, Brisbane, Qld 4029, Australia
推荐引用方式 GB/T 7714	Tan, Yuen Ping,Agnew-Francis, Kylie A.,Hofmann, Julian,et al. Humulene Diepoxides from the Australian Arid Zone Herb Dysphania: Assignment of Aged Hops Constituents[J],2020,26(7):1653-1660.
APA	Tan, Yuen Ping.,Agnew-Francis, Kylie A..,Hofmann, Julian.,Savchenko, Andrei, I.,Lafontaine, Scott R..,...&Williams, Craig M..(2020).Humulene Diepoxides from the Australian Arid Zone Herb Dysphania: Assignment of Aged Hops Constituents.CHEMISTRY-A EUROPEAN JOURNAL,26(7),1653-1660.
MLA	Tan, Yuen Ping,et al."Humulene Diepoxides from the Australian Arid Zone Herb Dysphania: Assignment of Aged Hops Constituents".CHEMISTRY-A EUROPEAN JOURNAL 26.7(2020):1653-1660.