干旱区生态环境知识资源中心(Arid): Serological Evidence of Yersiniosis, Tick-Borne Encephalitis, West Nile, Hepatitis E, Crimean-Congo Hemorrhagic Fever, Lyme Borreliosis, and Brucellosis in Febrile Patients Presenting at Diverse Hospitals in Kenya

Arid

DOI	10.1089/vbz.2019.2484
	Serological Evidence of Yersiniosis, Tick-Borne Encephalitis, West Nile, Hepatitis E, Crimean-Congo Hemorrhagic Fever, Lyme Borreliosis, and Brucellosis in Febrile Patients Presenting at Diverse Hospitals in Kenya
	Nyataya, Josphat 1; Maraka, Moureen 1; Lemtudo, Allan 1; Masakhwe, Clement 1; Mutai, Beth 1; Njaanake, Kariuki 2; Estambale, Benson B.3; Nyakoe, Nancy 4; Siangla, Joram 1; Waitumbi, John Njenga 1
通讯作者	Waitumbi, John Njenga
来源期刊	VECTOR-BORNE AND ZOONOTIC DISEASES
ISSN	1530-3667
EISSN	1557-7759
出版年	2020
卷号	20 期号:5 页码:348-357
英文摘要	Data on pathogen prevalence is crucial for informing exposure and disease risk. We evaluated serological evidence of tick-borne encephalitis (TBE), West Nile (WN), Hepatitis E virus (HEV), Crimean-Congo Hemorrhagic Fever (CCHF), Yersiniosis, Lyme Disease (LD), and brucellosis in 1033 patients presenting with acute febrile illness at 9 health care facilities from diverse ecological zones of Kenya: arid and semiarid (Garissa District Hospital, Lodwar District Hospital, Marigat District Hospital, Gilgil District Hospital), Lake Victoria basin (Kisumu District Hospital, Alupe District Hospital, Kombewa Sub-County Hospital), Kisii highland (Kisii District Hospital), and coastal (Malindi District Hospital). Epidemiological information of the patients such as geography, age, gender, and keeping animals were analyzed as potential risk factors. Of the 1033 samples, 619 (59.9%) were seropositive to at least one pathogen by IgM (current exposure), IgG/IgM (recent exposure), and IgG (past exposure). Collective seroprevalence for current, recent, and past to the pathogens was 9.4%, 5.1%, and 21.1% for LD; 3.6%, 0.5%, and 12.4% for WN; 0.9%, 0.5%, and 16.9% for HEV; 5.8%, 1.3%, and 3.9% for brucellosis; 5.7%, 0.2%, and 2.3% for yersiniosis; 1.7%, 0%, and 6.2% for TBE; and 0.4%, 0%, and 1.9% for CCHF. Brucellosis risk was higher in patients recruited at Garissa District Hospital (odds ratio [OR] = 3.41), HEV (OR = 2.45) and CCHF (OR = 5.46) in Lodwar District Hospital, LD in Alupe District Hospital (OR = 5.73), Kombewa Sub-district hospital (OR = 8.17), and Malindi District hospital (OR = 3.3). Exposure to LD was highest in the younger age group, whereas yersiniosis did not vary with age. Age was a significant risk for WN, brucellosis, CCHF, TBE, and HEV and in those aged >14 years there was an increased risk to WN (OR = 2.30, p < 0.0001), brucellosis (OR = 1.84, p = 0.005), CCHF (OR = 4.35, p = 0.001), TBE (OR = 2.78, p < 0.0001), and HEV (OR = 1.94, p = 0.0001). We conclude that LD is pervasive and constitutes a significant health burden to the study population, whereas yersiniosis and CCHF are not significant threats. Going forward, community-based studies will be needed to capture the true seroprevalence rates and the associated risk factors.
英文关键词	yersiniosis tick-borne encephalitis West Nile Crimean-Congo hemorrhagic fever lyme borreliosis brucellosis
类型	Article
语种	英语
国家	Kenya ; Ghana
收录类别	SCI-E
WOS记录号	WOS:000507910300001
WOS关键词	VIRUS TRANSMISSION ; ILLNESS ; EPIDEMIOLOGY ; SURVEILLANCE ; MOSQUITOS ; ENTEROCOLITICA ; CHILDREN ; DISEASE ; SEROPREVALENCE ; ARBOVIRUSES
WOS类目	Public, Environmental & Occupational Health ; Infectious Diseases
WOS研究方向	Public, Environmental & Occupational Health ; Infectious Diseases
EI主题词	2020-01-13
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/312460
作者单位	1.Kenya Govt Med Res Ctr, Basic Sci Lab, Med Res Directorate Africa, POB 54-40100, Kisumu, Kenya; 2.Univ Nairobi, Coll Hlth Sci, Dept Med Microbiol, Nairobi, Kenya; 3.Jaram Oginga Odinga Univ Sci & Technol, Div Res Innovat & Outreach, Bondo, Kenya; 4.Univ Ghana, WACCBIP, Dept Biochem Cell & Mol Biol, Accra, Ghana
推荐引用方式 GB/T 7714	Nyataya, Josphat,Maraka, Moureen,Lemtudo, Allan,et al. Serological Evidence of Yersiniosis, Tick-Borne Encephalitis, West Nile, Hepatitis E, Crimean-Congo Hemorrhagic Fever, Lyme Borreliosis, and Brucellosis in Febrile Patients Presenting at Diverse Hospitals in Kenya[J],2020,20(5):348-357.
APA	Nyataya, Josphat.,Maraka, Moureen.,Lemtudo, Allan.,Masakhwe, Clement.,Mutai, Beth.,...&Waitumbi, John Njenga.(2020).Serological Evidence of Yersiniosis, Tick-Borne Encephalitis, West Nile, Hepatitis E, Crimean-Congo Hemorrhagic Fever, Lyme Borreliosis, and Brucellosis in Febrile Patients Presenting at Diverse Hospitals in Kenya.VECTOR-BORNE AND ZOONOTIC DISEASES,20(5),348-357.
MLA	Nyataya, Josphat,et al."Serological Evidence of Yersiniosis, Tick-Borne Encephalitis, West Nile, Hepatitis E, Crimean-Congo Hemorrhagic Fever, Lyme Borreliosis, and Brucellosis in Febrile Patients Presenting at Diverse Hospitals in Kenya".VECTOR-BORNE AND ZOONOTIC DISEASES 20.5(2020):348-357.