干旱区生态环境知识资源中心(Arid): Molecular characterization and distribution of the voltage-gated sodium channel, Para, in the brain of the grasshopper and vinegar fly

Arid

DOI	10.1007/s00359-019-01396-4
	Molecular characterization and distribution of the voltage-gated sodium channel, Para, in the brain of the grasshopper and vinegar fly
	Wang, Hongxia 1; Foquet, Bert 2; Dewell, Richard B.1; Song, Hojun 2; Dierick, Herman A.1,3; Gabbiani, Fabrizio 1,4
通讯作者	Gabbiani, Fabrizio
来源期刊	JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
ISSN	0340-7594
EISSN	1432-1351
出版年	2020
卷号	206 期号:2 页码:289-307
英文摘要	Voltage-gated sodium (NaV) channels, encoded by the gene para, play a critical role in the rapid processing and propagation of visual information related to collision avoidance behaviors. We investigated their localization by immunostaining the optic lobes and central brain of the grasshopper Schistocerca americana and the vinegar fly Drosophila melanogaster with an antibody that recognizes the channel peptide domain responsible for fast inactivation gating. NaV channels were detected at high density at all stages of development. In the optic lobe, they revealed stereotypically repeating fascicles consistent with the regular structure of the eye. In the central brain, major axonal tracts were strongly labeled, particularly in the grasshopper olfactory system. We used the NaV channel sequence of Drosophila to identify an ortholog in the transcriptome of Schistocerca. The grasshopper, vinegar fly, and human NaV channels exhibit a high degree of conservation at gating and ion selectivity domains. Comparison with three species evolutionarily close to Schistocerca identified splice variants of Para and their relation to those of Drosophila. The anatomical distribution of NaV channels molecularly analogous to those of humans in grasshoppers and vinegar flies provides a substrate for rapid signal propagation and visual processing in the context of visually-guided collision avoidance.
英文关键词	Drosophila Schistocerca Pan-Nav Para Optic lobe
类型	Article
语种	英语
国家	USA
开放获取类型	Green Accepted
收录类别	SCI-E
WOS记录号	WOS:000505412200001
WOS关键词	QUALITY ASSESSMENT ; INACTIVATION GATE ; DESERT LOCUST ; CD-HIT ; GENE ; EXPRESSION ; RESIDUES ; INFORMATION ; ASSOCIATION ; SELECTIVITY
WOS类目	Behavioral Sciences ; Neurosciences ; Physiology ; Zoology
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology ; Physiology ; Zoology
EI主题词	2020-01-04
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/312387
作者单位	1.Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA; 2.Texas A&M Univ, Dept Entomol, College Stn, TX 77843 USA; 3.Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA; 4.Rice Univ, Dept Elect & Comp Engn, POB 1892, Houston, TX 77251 USA
推荐引用方式 GB/T 7714	Wang, Hongxia,Foquet, Bert,Dewell, Richard B.,et al. Molecular characterization and distribution of the voltage-gated sodium channel, Para, in the brain of the grasshopper and vinegar fly[J],2020,206(2):289-307.
APA	Wang, Hongxia,Foquet, Bert,Dewell, Richard B.,Song, Hojun,Dierick, Herman A.,&Gabbiani, Fabrizio.(2020).Molecular characterization and distribution of the voltage-gated sodium channel, Para, in the brain of the grasshopper and vinegar fly.JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY,206(2),289-307.
MLA	Wang, Hongxia,et al."Molecular characterization and distribution of the voltage-gated sodium channel, Para, in the brain of the grasshopper and vinegar fly".JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY 206.2(2020):289-307.