干旱区生态环境知识资源中心(Arid): HSP70 plays a role in the defense of acute and chronic heat stress in Mongolian gerbils (Meriones unguiculatus)

Arid

DOI	10.1016/j.jtherbio.2019.102452
	HSP70 plays a role in the defense of acute and chronic heat stress in Mongolian gerbils (Meriones unguiculatus)
	Lou, Shu-Lei 1,2; Zhang, Xue-Ying 1,2; Wang, De-Hua 1,2
通讯作者	Zhang, Xue-Ying ; Wang, De-Hua
来源期刊	JOURNAL OF THERMAL BIOLOGY
ISSN	0306-4565
出版年	2019
卷号	86
英文摘要	Mongolian gerbils (Meriones unguiculatus) show a wide thermal neutral zone (TNZ, 26.5-38.9 degrees C). Whether heat shock proteins (HSPs) are involved in thermal tolerance for gerbils has still been unknown. We investigated the effects of acute and chronic high temperature within and above TNZ on the expressions of HSP70 and HSP90 and oxidative status in Mongolian gerbils, to test the hypothesis that the gerbils need increase the expression in HSPs to defense the acute and chronic heat stress. In experiment I, 50 Mongolian gerbils were exposed to 23 degrees C, 27 degrees C, 37 degrees C, 40 degrees C and 43.5 degrees C for 80 min respectively, and then sacrificed 12 h after treatment. HSP70 expression in the liver increased at 40 degrees C compared to that at 23 degrees C, but did not change after 27 degrees C, 37 degrees C or 43.5 degrees C exposure. There were no differences in HSP90 expression, oxidative stress parameters such as malonaldehyde (MDA) and hydrogen peroxide (H2O2), or antioxidant parameters such as superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) in the liver. HSP70 and HSP90 expression both in the heart and brain showed no differences among groups. In experiment H, another set of 30 gerbils were acclimated to 23 degrees C, 27 degrees C and 37 degrees C for 21 days, respectively. During chronic acclimation, HSP70 expression increased and H2O2 level decreased in the liver in 37 degrees C group compared to other two groups. Both H2O2 and SOD in the brain decreased in 37 degrees C group, but there were no differences in HSP70, MDA or T-AOC in the brain. These data indicate that Mongolian gerbils can maintain basal levels of HSPs after acute exposure to temperatures within the wide TNZ, but rely on increased HSP70 in the liver to protect from heat damage at temperatures above TNZ and during chronic heat acclimation. The increased HSP70 expression in the liver may contribute to keeping from heat damage in desert rodents.
英文关键词	High temperature Heat shock proteins (HSPs) Oxidative stress Thermal neutral zone (TNZ) Mongolian gerbils (Meriones unguiculatus)
类型	Article
语种	英语
国家	Peoples R China
收录类别	SCI-E
WOS记录号	WOS:000501652200018
WOS关键词	HISTORY TRADE-OFFS ; OXIDATIVE STRESS ; SHOCK PROTEINS ; TIME-COURSE ; MOLECULAR CHAPERONES ; GEOGRAPHIC-VARIATION ; THERMONEUTRAL ZONE ; SKELETAL-MUSCLE ; LIVER-INJURY ; EXPRESSION
WOS类目	Biology ; Zoology
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Zoology
EI主题词	2019-12-01
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/311408
作者单位	1.Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pests Insects, Beijing 100101, Peoples R China; 2.Univ Chinese Acad Sci, CAS Ctr Excellence Biot Interact, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Lou, Shu-Lei,Zhang, Xue-Ying,Wang, De-Hua. HSP70 plays a role in the defense of acute and chronic heat stress in Mongolian gerbils (Meriones unguiculatus)[J],2019,86.
APA	Lou, Shu-Lei,Zhang, Xue-Ying,&Wang, De-Hua.(2019).HSP70 plays a role in the defense of acute and chronic heat stress in Mongolian gerbils (Meriones unguiculatus).JOURNAL OF THERMAL BIOLOGY,86.
MLA	Lou, Shu-Lei,et al."HSP70 plays a role in the defense of acute and chronic heat stress in Mongolian gerbils (Meriones unguiculatus)".JOURNAL OF THERMAL BIOLOGY 86(2019).