干旱区生态环境知识资源中心(Arid): Neurobehavioral effects of acute and chronic lead exposure in a desert rodent Meriones shawi: Involvement of serotonin and dopamine

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DOI	10.1016/j.jchemneu.2019.101689
	Neurobehavioral effects of acute and chronic lead exposure in a desert rodent Meriones shawi: Involvement of serotonin and dopamine
	Mustapha Bouyatas, Moulay 1,2; Abbaoui, Abdellatif 1; Gamrani, Halima 1
通讯作者	Gamrani, Halima
来源期刊	JOURNAL OF CHEMICAL NEUROANATOMY
ISSN	0891-0618
EISSN	1873-6300
出版年	2019
卷号	102
英文摘要	Lead (Pb) is a non physiological metal that has been implicated in toxic processes affecting several organs and biological systems, including the central nervous system. Several studies have focused on changes in lead-associated neurobehavioral and neurochemical alterations that occur due to Pb exposure. The present study evaluates the effects of acute and chronic Pb acetate exposure on serotoninergic and dopaminergic systems within the dorsal raphe nucleus, regarding motor activity and anxiety behaviours. Experiments were carried out on adult male Meriones shawi exposed to acute lead acetate intoxication (25 mg/kg b.w., 3 i.p. injections) or to a chronic lead exposure (0,5%) in drinking water from intrauterine age to adult age. Immunohistochemical staining demonstrated that both acute and chronic lead exposure increased anti-serotonin (anti-5HT) and tyrosine hydroxylase (anti-TH) immuno-reactivities in the dorsal raphe nucleus. In parallel, our results demonstrated that a long term Pb-exposure, but not an acute lead intoxication, induced behavioural alterations including, hyperactivity (open field test), and anxiogenic like-effects. Such neurobehavioral impairments induced by Pb-exposure in Meriones shawi may be related to dopaminergic and serotoninergic injuries identified in the dorsal raphe nucleus.
英文关键词	Lead-exposure Meriones shawi Locomotion Anxiety Serotonin Dopamine
类型	Article
语种	英语
国家	Morocco
收录类别	SCI-E
WOS记录号	WOS:000501402800003
WOS关键词	LOW-LEVEL LEAD ; CATECHOLAMINE LEVELS ; MONOAMINE-OXIDASE ; ANXIETY ; BRAIN ; INTOXICATION ; BEHAVIOR ; SYSTEM ; MOTOR ; NEUROTOXICITY
WOS类目	Biochemistry & Molecular Biology ; Neurosciences
WOS研究方向	Biochemistry & Molecular Biology ; Neurosciences & Neurology
EI主题词	2019-12-01
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/311372
作者单位	1.Cadi Ayyad Univ, Fac Sci Semlalia, Neurosci Pharmacol & Environm Unit, Ave My Abdellah,BP 2390, Marrakech, Morocco; 2.Cadi Ayyad Univ, Multidisciplinary Fac Safi, Dept Biol, Marrakech, Morocco
推荐引用方式 GB/T 7714	Mustapha Bouyatas, Moulay,Abbaoui, Abdellatif,Gamrani, Halima. Neurobehavioral effects of acute and chronic lead exposure in a desert rodent Meriones shawi: Involvement of serotonin and dopamine[J],2019,102.
APA	Mustapha Bouyatas, Moulay,Abbaoui, Abdellatif,&Gamrani, Halima.(2019).Neurobehavioral effects of acute and chronic lead exposure in a desert rodent Meriones shawi: Involvement of serotonin and dopamine.JOURNAL OF CHEMICAL NEUROANATOMY,102.
MLA	Mustapha Bouyatas, Moulay,et al."Neurobehavioral effects of acute and chronic lead exposure in a desert rodent Meriones shawi: Involvement of serotonin and dopamine".JOURNAL OF CHEMICAL NEUROANATOMY 102(2019).