干旱区生态环境知识资源中心(Arid): Preoperative Radiomic Approach to Evaluate Tumor-Infiltrating CD8(+) T Cells in Hepatocellular Carcinoma Patients Using Contrast-Enhanced Computed Tomography

Arid

DOI	10.1245/s10434-019-07815-9
	Preoperative Radiomic Approach to Evaluate Tumor-Infiltrating CD8(+) T Cells in Hepatocellular Carcinoma Patients Using Contrast-Enhanced Computed Tomography
	Liao, Haotian 1,4; Zhang, Zhen 2; Chen, Jie 2; Liao, Mingheng 1,4; Xu, Lin 1,4; Wu, Zhenru 3; Yuan, Kefei 1,4; Song, Bin 2; Zeng, Yong 1,4
通讯作者	Song, Bin
来源期刊	ANNALS OF SURGICAL ONCOLOGY
ISSN	1068-9265
EISSN	1534-4681
出版年	2019
卷号	26 期号:13 页码:4537-4547
英文摘要	Background. To help identify potential hepatocellular carcinoma (HCC) candidates for immunotherapies, we aimed to develop and validate a radiomics-based biomarker (Rad score) to predict the infiltration of tumor-infiltrating CD8(+) T cells in HCC patients, and to evaluate the correlation of Rad score with tumor immune characteristics. Methods. Overall, 142 HCC patients (n = 100 and n = 42 in the training and validation sets, respectively) were subjected to radiomic feature extraction. Imaging features and immunochemistry data of patients in the training set were subjected to elastic-net regularized regression analysis to predict the level of CD8(+) T cell infiltration. Results. A Rad score for CD8(+) T-cell infiltration, which contained seven variables, was developed and was validated in the validation set (area under the curve [AUC]: training set 0.751, 95% confidence interval [CI] 0.656-0.846; validation set 0.705, 95% CI 0.547-0.863). The decision curve indicated the clinical usefulness of the Rad score. A higher Rad score correlated with superior overall and disease-free survival outcomes (p = 0.012 and 0.0088, respectively). Using the pathological slides, we found that the Rad score positively correlated with the percentage of tumor-infiltrating lymphocytes (TILs; Spearman rho = 0.51, p < 0.0001). Moreover, the Rad score could also discriminate inflamed tumors from immune-desert and immune-excluded tumors (Kruskal-Wallis, p < 0.0001), and higher Rad scores could be found in patients with positive programmed cell death ligand 1 expression in tumor/immune cells, as well as those with positive programmed cell death protein 1 expression. Conclusion. The newly developed Rad score was a powerful predictor of CD8(+) T-cell infiltration, which could be useful in identifying potential HCC patients who can benefit from immunotherapies when validated in large-scale prospective cohorts.
类型	Article
语种	英语
国家	Peoples R China
收录类别	SCI-E
WOS记录号	WOS:000506884200056
WOS关键词	IMMUNE CELLS ; BLOCKADE ; SURVIVAL ; PEMBROLIZUMAB ; EXPRESSION ; IMAGES
WOS类目	Oncology ; Surgery
WOS研究方向	Oncology ; Surgery
EI主题词	2019-12-01
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/311223
作者单位	1.Sichuan Univ, West China Hosp, Dept Liver Surg, Liver Transplantat Div, Chengdu, Sichuan, Peoples R China; 2.Sichuan Univ, West China Hosp, Dept Radiol, Chengdu, Sichuan, Peoples R China; 3.Sichuan Univ, West China Hosp, Dept Pathol, Lab Pathol, Chengdu, Sichuan, Peoples R China; 4.Sichuan Univ, West China Hosp, Lab Liver Surg, Chengdu, Sichuan, Peoples R China
推荐引用方式 GB/T 7714	Liao, Haotian,Zhang, Zhen,Chen, Jie,et al. Preoperative Radiomic Approach to Evaluate Tumor-Infiltrating CD8(+) T Cells in Hepatocellular Carcinoma Patients Using Contrast-Enhanced Computed Tomography[J],2019,26(13):4537-4547.
APA	Liao, Haotian.,Zhang, Zhen.,Chen, Jie.,Liao, Mingheng.,Xu, Lin.,...&Zeng, Yong.(2019).Preoperative Radiomic Approach to Evaluate Tumor-Infiltrating CD8(+) T Cells in Hepatocellular Carcinoma Patients Using Contrast-Enhanced Computed Tomography.ANNALS OF SURGICAL ONCOLOGY,26(13),4537-4547.
MLA	Liao, Haotian,et al."Preoperative Radiomic Approach to Evaluate Tumor-Infiltrating CD8(+) T Cells in Hepatocellular Carcinoma Patients Using Contrast-Enhanced Computed Tomography".ANNALS OF SURGICAL ONCOLOGY 26.13(2019):4537-4547.