干旱区生态环境知识资源中心(Arid): Whey protein polymorphisms in Sudanese goat breeds

Arid

DOI	10.1007/s11250-019-02119-2
	Whey protein polymorphisms in Sudanese goat breeds
	Rahmatalla, Siham A.1,2; Arends, Danny 1; Ahmed, Ammar Said 1; Reissmann, Monika 1; Brockmann, Gudrun A.1
通讯作者	Rahmatalla, Siham A. ; Brockmann, Gudrun A.
来源期刊	TROPICAL ANIMAL HEALTH AND PRODUCTION
ISSN	0049-4747
EISSN	1573-7438
出版年	2020
卷号	52 期号:3 页码:1211-1222
英文摘要	The aim of the present study was to assess genetic variation that is characteristic for Sudanese goat breeds in the milk whey protein genes (LALBA and BLG). Four Sudanese goat breeds were screened for variability in LALBA and BLG genes at the DNA level by comparative sequencing of five animals per breed. Sixteen SNPs were identified in LALBA: seven in the upstream region, six synonymous, and three in the 3 '-UTR. Three novel synonymous SNPs in exon 2 (ss5197800003, ss5197800012, and ss5197800004) were found in Nubian, Desert, and Nilotic, but not in Taggar goats. One SNP in the promoter of LALBA (rs642745519) modifies a predicted transcription factor binding site for Tcfe2a. The SNPs in the 3'-UTR (rs657915405, rs641559728, and rs664225585) affect predicted miRNA target sites. With respect to haplotypes in the exonic region, haplotype LALBA-A is most frequent in Nubian, Desert, and Nilotic goats, while haplotype LALBA-D is prevalent in Taggar goats. In BLG, 30 SNPs were detected: eight in the upstream gene region, two synonymous, 17 intronic, and three in the 3'-UTR. Among the 30 identified SNPs, 15 were novel. Four of these novel SNPs were located in the upstream gene region, one was synonymous, and ten were intronic. The novel synonymous SNP (ss5197800017), located in exon 2, was only found in Nubian and Nilotic goats. The SNPs ss5197800010 and rs635615192 in the promoter are located in predicted binding sites of transcription factors (M6097, Elk3, Elf5, and GABPA). Among seven haplotypes detected in the coding region, haplotype BLG-A is most frequent in Nubian and Nilotic goats while haplotype BLG-B is most frequent in Desert and Taggar goats. The high variability in regulatory gene regions among Sudanese goats could potentially affect the quality and yield of whey proteins in goat milk and provide a wide resource for genetic improvement of milk production and milk technology characteristics.
英文关键词	Whey protein Sudanese goat breeds Single nucleotide polymorphism Genetic diversity
类型	Article
语种	英语
国家	Germany ; Sudan
收录类别	SCI-E
WOS记录号	WOS:000499189600001
WOS关键词	SINGLE NUCLEOTIDE POLYMORPHISM ; BOVINE BETA-LACTOGLOBULIN ; ALPHA-LACTALBUMIN ; RENNETING PROPERTIES ; LALBA GENE ; MILK-YIELD ; CATTLE ; ASSOCIATION ; TRAITS ; VARIABILITY
WOS类目	Agriculture, Dairy & Animal Science ; Veterinary Sciences
WOS研究方向	Agriculture ; Veterinary Sciences
EI主题词	2019-11-28
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/311006
作者单位	1.Humboldt Univ, Albrecht Daniel Thaer Inst Agrar & Gartenbauwisse, Invalidenstr 42, D-10115 Berlin, Germany; 2.Univ Khartoum, Fac Anim Prod, Dept Dairy Prod, POB 32, Shambat 13314, Khartoum North, Sudan
推荐引用方式 GB/T 7714	Rahmatalla, Siham A.,Arends, Danny,Ahmed, Ammar Said,et al. Whey protein polymorphisms in Sudanese goat breeds[J],2020,52(3):1211-1222.
APA	Rahmatalla, Siham A.,Arends, Danny,Ahmed, Ammar Said,Reissmann, Monika,&Brockmann, Gudrun A..(2020).Whey protein polymorphisms in Sudanese goat breeds.TROPICAL ANIMAL HEALTH AND PRODUCTION,52(3),1211-1222.
MLA	Rahmatalla, Siham A.,et al."Whey protein polymorphisms in Sudanese goat breeds".TROPICAL ANIMAL HEALTH AND PRODUCTION 52.3(2020):1211-1222.