干旱区生态环境知识资源中心(Arid): Solid-phase extraction based on cation-exchange sorbents followed by liquid chromatography high-resolution mass spectrometry to determine synthetic cathinones in urine

Arid

DOI	10.1007/s11419-019-00508-8
	Solid-phase extraction based on cation-exchange sorbents followed by liquid chromatography high-resolution mass spectrometry to determine synthetic cathinones in urine
	Pascual-Caro, Sergi; Fontanals, Nuria; Borrull, Francesc; Aguilar, Carme; Calull, Marta
通讯作者	Aguilar, Carme
来源期刊	FORENSIC TOXICOLOGY
ISSN	1860-8965
EISSN	1860-8973
出版年	2020
卷号	38 期号:1 页码:185-194
英文摘要	Purpose Cathinone derivates have become very popular as legal highs and are easily obtained on the market as bath salts, getting around the legislation due to their modified structure based on banned substances. The aim of this project is to evaluate two mixed-mode cation-exchange sorbents in solid-phase extraction (SPE) and their efficacy in pretreating urine samples for the determination of synthetic cathinones by liquid chromatography high-resolution mass spectrometry (LC-HRMS). Methods A method for determining a group of eleven trending synthetic cathinones in urine using SPE followed by LC-HRMS using Orbitrap as analyser was developed and validated. Results In the extraction step, two different cation-exchange sorbents were evaluated and compared, a weak one (Oasis WCX) and a strong one (Oasis MCX). Better results were obtained for Oasis MCX in terms of recoveries and matrix effects (lower, if a clean-up step was applied). Method quantification limits were set at 0.2 ng mL(-1) and method detection limits were between 0.04 and 0.16 ng mL(-1). Conclusions The results obtained enabled the studied compounds to be quantified at the usual levels at which they are present in urine samples. Moreover, these limits were lower than the ones found in the literature using similar extraction strategies, which shows that the reported strategy can be a useful tool in forensic and toxicological analyses.
英文关键词	Synthetic cathinones Solid-phase extraction Cation-exchange sorbents Liquid chromatography high-resolution mass spectrometry Urine samples
类型	Article
语种	英语
国家	Spain
收录类别	SCI-E
WOS记录号	WOS:000496233200002
WOS关键词	COMBINED IN-LINE ; PSYCHOACTIVE SUBSTANCES ; CHIRAL SEPARATION ; DESIGNER DRUGS ; EQUINE PLASMA ; WHOLE-BLOOD ; WASTE-WATER ; QUANTIFICATION ; IDENTIFICATION ; OPTIMIZATION
WOS类目	Toxicology
WOS研究方向	Toxicology
EI主题词	2019-11-13
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/310850
作者单位	Univ Rovira & Virgili, Dept Analyt Chem & Organ Chem, Campus Sescelades,Marcelli Domingo 1, E-43007 Tarragona, Spain
推荐引用方式 GB/T 7714	Pascual-Caro, Sergi,Fontanals, Nuria,Borrull, Francesc,et al. Solid-phase extraction based on cation-exchange sorbents followed by liquid chromatography high-resolution mass spectrometry to determine synthetic cathinones in urine[J],2020,38(1):185-194.
APA	Pascual-Caro, Sergi,Fontanals, Nuria,Borrull, Francesc,Aguilar, Carme,&Calull, Marta.(2020).Solid-phase extraction based on cation-exchange sorbents followed by liquid chromatography high-resolution mass spectrometry to determine synthetic cathinones in urine.FORENSIC TOXICOLOGY,38(1),185-194.
MLA	Pascual-Caro, Sergi,et al."Solid-phase extraction based on cation-exchange sorbents followed by liquid chromatography high-resolution mass spectrometry to determine synthetic cathinones in urine".FORENSIC TOXICOLOGY 38.1(2020):185-194.