干旱区生态环境知识资源中心(Arid): Distribution of aquaporins and sodium transporters in the gastrointestinal tract of a desert hare, Lepus yarkandensis

Arid

DOI	10.1038/s41598-019-53291-2
	Distribution of aquaporins and sodium transporters in the gastrointestinal tract of a desert hare, Lepus yarkandensis
	Zhang, Jianping 1,2,3,4; Li, Shuwei 1,2; Deng, Fang 1; Baikeli, Buheliqihan 1; Yu, Weijiang 1; Liu, Guoquan 3,4,5,6
通讯作者	Zhang, Jianping ; Liu, Guoquan
来源期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
出版年	2019
卷号	9
英文摘要	Lepus yarkandensis is a desert hare of the Tarim Basin in western China, and it has strong adaptability to arid environments. Aquaporins (AQPs) are a family of water channel proteins that facilitate transmembrane water transport. Gastrointestinal tract AQPs are involved in fluid absorption in the small intestine and colon. This study aimed to determine the distribution of AQPs and sodium transporters in the gastrointestinal tract of L. yarkandensis and to compare the expression of these proteins with that in Oryctolagus cuniculus. Immunohistochemistry was performed to analyse the cellular distribution of these proteins, and the acquired images were analysed with IpWin32 software. Our results revealed that AQP1was located in the colonic epithelium, central lacteal cells, fundic gland parietal cells, and capillary endothelial cells; AQP3 was located in the colonic epithelium, small intestinal villus epithelium, gastric pit and fundic gland; AQP4 was located in the fundic gland, small intestinal gland and colonic epithelium; and epithelial sodium channel (ENaC) and Na+-K+-ATPase were located in the epithelial cells, respectively. The higher expression levels of AQP1, AQP3, ENaC and Na+-K+-ATPase in the colon of L. yarkandensis compared to those in O. cuniculus suggested that L. yarkandensis has a higher capacity for faecal dehydration.
类型	Article
语种	英语
国家	Peoples R China
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000495857600093
WOS关键词	WATER CHANNEL ; MESSENGER-RNA ; LOCALIZATION ; COLON ; PROTEIN ; MECHANISMS ; EPITHELIA ; SECRETION ; AQP3
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
EI主题词	2019-11-12
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/310831
作者单位	1.Tarim Univ Alar, Coll Life Sci, Aral 843300, Xinjiang Provin, Peoples R China; 2.Tarim Univ Alar, Key Lab Biol Resources Protect & Utilizat Tarim B, Aral 843300, Xinjiang Provin, Peoples R China; 3.Bengbu Med Coll Bengbu, Sch Lab Med, Dept Biochem & Mol Biol, Bengbu 233030, Anhui, Peoples R China; 4.Bengbu Med Coll Bengbu, Anhui Prov Key Lab Translat Canc Res, Bengbu 233030, Anhui, Peoples R China; 5.Huazhong Agr Univ Wuhan, Coll Anim Sci & Vet Med, Dept Basic Vet Med, Wuhan 430070, Hubei, Peoples R China; 6.Huazhong Agr Univ Wuhan, Coll Anim Sci & Vet Med, Key Lab Swine Genet & Breeding & Agr Anim Breedin, Wuhan 430070, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jianping,Li, Shuwei,Deng, Fang,et al. Distribution of aquaporins and sodium transporters in the gastrointestinal tract of a desert hare, Lepus yarkandensis[J],2019,9.
APA	Zhang, Jianping,Li, Shuwei,Deng, Fang,Baikeli, Buheliqihan,Yu, Weijiang,&Liu, Guoquan.(2019).Distribution of aquaporins and sodium transporters in the gastrointestinal tract of a desert hare, Lepus yarkandensis.SCIENTIFIC REPORTS,9.
MLA	Zhang, Jianping,et al."Distribution of aquaporins and sodium transporters in the gastrointestinal tract of a desert hare, Lepus yarkandensis".SCIENTIFIC REPORTS 9(2019).