干旱区生态环境知识资源中心(Arid): Genetic selection for bovine chromosome 18 haplotypes associated with divergent somatic cell score affects postpartum reproductive and metabolic performance

Arid

DOI	10.3168/jds.2018-16171
	Genetic selection for bovine chromosome 18 haplotypes associated with divergent somatic cell score affects postpartum reproductive and metabolic performance
	Meyerholz, M. M.1,2; Rohmeier, L.1,3; Eickhoff, T.2; Huelsebusch, A.2; Jander, S.2; Linden, M.4; Macias, L.1; Koy, M.2,5; Heimes, A.6; Gorriz-Martin, L.7; Segelke, D.8; Engelmann, S.9,10; Schmicke, M.7; Hoedemaker, M.7; Petzl, W.1; Zerbe, H.1; Schuberth, H-J 2; Kuehn, Ch 6,11
通讯作者	Meyerholz, M. M.
来源期刊	JOURNAL OF DAIRY SCIENCE
ISSN	0022-0302
EISSN	1525-3198
出版年	2019
卷号	102 期号:11 页码:9983-9994
英文摘要	The susceptibility of animals to periparturient diseases has a great effect on the economic efficiency of dairy industries, on the frequency of antibiotic treatment, and on animal welfare. The use of selection for breeding cows with reduced susceptibility to diseases offers a sustainable tool to improve dairy cattle farming. Several studies have focused on the association of distinct bovine chromosome 18 genotypes or haplotypes with performance traits. The aim of this study was to test whether selection of Holstein Friesian heifers via SNP genotyping for alternative paternal chromosome 18 haplotypes associated with favorable (Q) or unfavorable (q) somatic cell scores influences postpartum reproductive and metabolic diseases. Thirty-six heifers (18 Q and 18 q) were monitored from 3 wk before calving until necropsy on d 39 (+/- 4 d) after calving. Health status and rectal temperature were measured daily, arid body condition score and body weight were assessed once per week. Blood samples were drawn twice weekly, and levels of insulin, nonesterified fatty acids, insulin-like growth factor-I, growth hormone, and beta-hydroxybutyrate were measured. Comparisons between the groups were performed using Fisher's exact test, chi-squared test, and the GLIMMIX procedure in SAS. Results showed that Q-heifers had reduced incidence of rnetritis compared with q-heifers and were less likely to develop fever. Serum concentrations of beta-hydroxybutyrate were lower and insulin-like growth factor-I plasma concentrations were higher in Q- compared with q-heifers. However, the body condition score and withers height were comparable between haplotypes, but weight loss tended to be lower in Q-heifers compared with q-heifers. No differences between the groups were detected concerning retained fetal membranes, uterine involution, or onset of cyclicity. In conclusion, selection of chromosome 18 haplotypes associated with a reduced somatic cell score resulted in a decreased incidence of postpartum reproductive and metabolic diseases in this study. The presented data add to the existing knowledge aimed at avoiding negative consequences of genetic selection strategies in dairy cattle farming. The underlying causal mechanisms modulated by haplotypes in the targeted genomic region and immune competence necessitate further investigation.
英文关键词	BTA18 somatic cell score metritis insulin-like growth factor-I
类型	Article
语种	英语
国家	Germany
开放获取类型	Green Published, Bronze
收录类别	SCI-E
WOS记录号	WOS:000489285000035
WOS关键词	TAURUS AUTOSOME 18 ; DAIRY-COWS ; SUBCLINICAL KETOSIS ; HOLSTEIN CATTLE ; GROWTH-HORMONE ; UTERINE HEALTH ; MANAGEMENT ; DISEASES ; TRAITS ; AXIS
WOS类目	Agriculture, Dairy & Animal Science ; Food Science & Technology
WOS研究方向	Agriculture ; Food Science & Technology
EI主题词	2019-11-01
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/310519
作者单位	1.Ludwig Maximilians Univ Munchen, Ctr Clin Vet Med, Clin Ruminants Ambulatory & Herd Hlth Serv, D-85764 Oberschleissheim, Germany; 2.Univ Vet Med, Immunol Unit, D-30559 Hannover, Germany; 3.Univ Vet Med, Clin Swine Small Ruminants Forens Med & Ambulator, D-30173 Hannover, Germany; 4.Leibniz Univ Hannover, Fac Math & Phys, D-30167 Hannover, Germany; 5.Univ Vet Med, Clin Poultry, D-30559 Hannover, Germany; 6.Leibniz Inst Farm Anim Biol, Genome Biol, D-18196 Dummerstorf, Germany; 7.Univ Vet Med, Clin Cattle, D-30173 Hannover, Germany; 8.Vereinigte Informat Syst Tierhaltung wV VIT Verde, D-27283 Verden, Aller, Germany; 9.Tech Univ, Inst Microbiol, D-38106 Braunschweig, Germany; 10.Helmholtz Ctr Infect Res, Microbial Prote, D-38124 Braunschweig, Germany; 11.Univ Rostock, Agr & Environm Fac, D-18059 Rostock, Germany
推荐引用方式 GB/T 7714	Meyerholz, M. M.,Rohmeier, L.,Eickhoff, T.,et al. Genetic selection for bovine chromosome 18 haplotypes associated with divergent somatic cell score affects postpartum reproductive and metabolic performance[J],2019,102(11):9983-9994.
APA	Meyerholz, M. M..,Rohmeier, L..,Eickhoff, T..,Huelsebusch, A..,Jander, S..,...&Kuehn, Ch.(2019).Genetic selection for bovine chromosome 18 haplotypes associated with divergent somatic cell score affects postpartum reproductive and metabolic performance.JOURNAL OF DAIRY SCIENCE,102(11),9983-9994.
MLA	Meyerholz, M. M.,et al."Genetic selection for bovine chromosome 18 haplotypes associated with divergent somatic cell score affects postpartum reproductive and metabolic performance".JOURNAL OF DAIRY SCIENCE 102.11(2019):9983-9994.