干旱区生态环境知识资源中心(Arid): Population Structure and Genetic Diversity among Isolates of Coccidioides posadasii in Venezuela and Surrounding Regions

Arid

DOI	10.1128/mBio.01976-19
	Population Structure and Genetic Diversity among Isolates of Coccidioides posadasii in Venezuela and Surrounding Regions
	Teixeira, Marcus M.1,2,3; Alvarado, Primavera 4; Roe, Chandler C.1,2; Thompson, George R., III 5; Patane, Jose S. L.6; Sahl, Jason W.2; Keim, Paul 1,2; Galgiani, John N.7; Litvintseva, Anastasia P.8; Matute, Daniel R.9; Barker, Bridget M.1,2
通讯作者	Barker, Bridget M.
来源期刊	MBIO
ISSN	2150-7511
出版年	2019
卷号	10 期号:6
英文摘要	Coccidioides posadasii is a pathogenic fungus that causes coccidioidomycosis in many arid regions of the Americas. One of these regions is bordered by the Caribbean Sea, and the surrounding landscape may play an important role in the dispersion of C. posadasii across South America through southeastern Mexico, Honduras, Guatemala, and Venezuela. Comparative phylogenomic analyses of C. posadasii reveal that clinical strains from Venezuela are genetically distinct from the North American populations found in (i) Arizona and (ii) Texas, Mexico, and the rest of South America (TX/MX/SA). We find evidence for admixture between the Venezuela and the North American populations of C. posadasii in Central America. Additionally, the proportion of Venezuelan alleles in the admixed population decreases as latitude (and distance from Venezuela) increases. Our results indicate that the population in Venezuela may have been subjected to a recent bottleneck and shows a strong population structure. This analysis provides insight into potential for Coccidioides spp. to invade new regions. IMPORTANCE Valley Fever is a fungal disease caused by two species of fungi: Coccidioides immitis and C. posadasii. These fungi are found throughout the arid regions of North and South America; however, our understanding of genetic diversity and disease in South America is limited. In this report, we analyze 10 new genomes of Coccidioides posadasii from regions bordering the Caribbean Sea. We show that these populations are distinct and that isolates from Venezuela are likely a result of a recent bottleneck. These data point to patterns that might be observed when investigating recently established populations.
英文关键词	coccidioidomycosis Venezuela Coccidioides posadasii Caribbean Valley Fever
类型	Article
语种	英语
国家	USA ; Brazil ; Venezuela
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000500484800048
WOS关键词	LATITUDINAL GRADIENT ; SOUTH-AMERICA ; FUNGAL ; EVOLUTION ; IMMITIS ; HYBRIDIZATION ; SPECIATION ; ADMIXTURE ; CALIFORNIA ; FRAMEWORK
WOS类目	Microbiology
WOS研究方向	Microbiology
EI主题词	2019-11-01
来源机构	University of Arizona ; University of California, Davis
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/310456
作者单位	1.City Hope Natl Med Ctr, Translat Genom Res Inst TGen, Flagstaff, AZ 86001 USA; 2.No Arizona Univ, Pathogen & Microbiome Inst, Flagstaff, AZ 86011 USA; 3.Univ Brasilia, Nucleo Medicina Trop, Fac Med, Brasilia, DF, Brazil; 4.Serv Autonomo Inst Biomed Dr Jacinto Concit, Caracas, Venezuela; 5.Div Infect Dis, UC Davis Med Ctr, Dept Med & Med Microbiol & Immunol, Sacramento, CA USA; 6.Inst Butantan, Lab Especial Ciclo Celular, Sao Paulo, Brazil; 7.Univ Arizona, Valley Fever Ctr Excellence, Coll Med, Tucson, AZ USA; 8.Mycot Dis Branch, Centers Dis Control & Prevent, Atlanta, GA USA; 9.Univ N Carolina, Dept Biol, Chapel Hill, NC USA
推荐引用方式 GB/T 7714	Teixeira, Marcus M.,Alvarado, Primavera,Roe, Chandler C.,et al. Population Structure and Genetic Diversity among Isolates of Coccidioides posadasii in Venezuela and Surrounding Regions[J]. University of Arizona, University of California, Davis,2019,10(6).
APA	Teixeira, Marcus M..,Alvarado, Primavera.,Roe, Chandler C..,Thompson, George R., III.,Patane, Jose S. L..,...&Barker, Bridget M..(2019).Population Structure and Genetic Diversity among Isolates of Coccidioides posadasii in Venezuela and Surrounding Regions.MBIO,10(6).
MLA	Teixeira, Marcus M.,et al."Population Structure and Genetic Diversity among Isolates of Coccidioides posadasii in Venezuela and Surrounding Regions".MBIO 10.6(2019).