Knowledge Resource Center for Ecological Environment in Arid Area
| DOI | 10.1016/j.fitote.2019.104291 |
| Bioactive constituents study of Pugionium cornutum L. Gaertn on intestinal motility | |
Shi, Wenzhong1; Ruan, Jingya2; Guo, Yuanqiang3; Ding, Zhijuan2; Yan, Jiejing1; Qu, Lu1; Zheng, Chang2; Zhang, Yi1,2; Wang, Tao1,2
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| 通讯作者 | Zhang, Yi ; Wang, Tao |
| 来源期刊 | FITOTERAPIA
 |
| ISSN | 0367-326X |
| EISSN | 1873-6971 |
| 出版年 | 2019 |
| 卷号 | 138 |
| 英文摘要 | Thirty-one compounds were obtained and identified from the dried roots of Mongolian medicinal and edible plant, Pugionium cornutum L. Gaertn. Eight of them were new ones, and named as pugcomols A (1), B (2), C (3), and D (4), pugcornosides A (5), B (6), C (7), and D (8), respectively. Among them, 1-4 were rare naturally occurring thiohydantoin derivatives. Meanwhile, all the isolates were determined for their activities on isolated mice jejunum contraction, and ten of them increased height of the spontaneous contractions. Moreover, we partly clarified the mechanism of 5-(methylsulfiny1)-pentanenitrile (9), a characteristic compound in P. cornutum by using different kinds of inhibitor. |
| 英文关键词 | Traditional Mongolian Medicine Pugionium cornutum L. Gaertn Thiohydantoin derivatives Intestinal motility Mice isolated intestine tissue 5-(methylsulfinyl)-pentanenitrile |
| 类型 | Article |
| 语种 | 英语 |
| 国家 | Peoples R China |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000498290700005 |
| WOS关键词 | OLEANANE TYPE SAPONINS ; DESERTIFICATION ; GLUCOSIDES ; LIGNANS ; SEEDS ; STEMS |
| WOS类目 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| WOS研究方向 | Pharmacology & Pharmacy |
| EI主题词 | 2019-10-01 |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/310236 |
| 作者单位 | 1.Tianjin State Key Lab Modern Chinese Med, 312 Anshanxi Rd, Tianjin 300193, Peoples R China; 2.Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin Key Lab TCM Chem & Anal, 312 Anshanxi Rd, Tianjin 300193, Peoples R China; 3.Nankai Univ, Coll Chem, Tianjin Key Lab Mol Drug Res, Tianjin 300071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Wenzhong,Ruan, Jingya,Guo, Yuanqiang,et al. Bioactive constituents study of Pugionium cornutum L. Gaertn on intestinal motility[J],2019,138. |
| APA | Shi, Wenzhong.,Ruan, Jingya.,Guo, Yuanqiang.,Ding, Zhijuan.,Yan, Jiejing.,...&Wang, Tao.(2019).Bioactive constituents study of Pugionium cornutum L. Gaertn on intestinal motility.FITOTERAPIA,138. |
| MLA | Shi, Wenzhong,et al."Bioactive constituents study of Pugionium cornutum L. Gaertn on intestinal motility".FITOTERAPIA 138(2019). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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