干旱区生态环境知识资源中心(Arid): Comprehensive transcriptome analysis of adipose tissue in the Bactrian camel reveals fore hump has more specific physiological functions in immune and endocrine systems

Arid

DOI	10.1016/j.livsci.2019.09.003
	Comprehensive transcriptome analysis of adipose tissue in the Bactrian camel reveals fore hump has more specific physiological functions in immune and endocrine systems
	Guo Fucheng 1; Si Rendalai 2; He Jing 1; Yuan Liyun 3; Hai Le 1; Ming Liang 1; Yi Li 1; Ji Rimutu 1,2
通讯作者	Ji Rimutu
来源期刊	LIVESTOCK SCIENCE
ISSN	1871-1413
EISSN	1878-0490
出版年	2019
卷号	228 页码:195-200
英文摘要	The unique hump structure of the Bactrian camel has helped it adapt to the harsh desert environment, and the adipose tissue contained in the hump is believed to play important roles in its survival. We used RNA sequencing to examine the transcriptome profiles of 7 adipose tissues of the fore hump, hind hump, subcutaneous, intermuscular, perihepatic, pericardial and peripheral tissues. A total of 4191 differentially expressed genes (DEGs) were identified between visceral fat (VF) and hump fat combined with subcutaneous fat (HS). Additionally, DEGs were also identified in the fore hump (FH), hind hump (HH) and subcutaneous fat (SC). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses of the identified DEGs showed that the hump has specialized immune and endocrine functions, in addition to its osmoregulatory roles. Further, DEGs involved in human diseases were significantly upregulated in visceral fat (VF), and DEGs associated with anti-hypertensive and anti-diabetic mechanisms were upregulated in HS. So HS seems to be more beneficial to health than visceral fat. Besides, fore hump has more immune and endocrine diverse genetic profile than subcutaneous fat. Thus, fore hump may be important for Bactrian camel's survival. Additional adaptation mechanisms should be further explored by obtaining more information on genetic and molecular mechanisms involved.
英文关键词	Camelus bactrianus Hump Transcriptome Survival
类型	Article
语种	英语
国家	Peoples R China
开放获取类型	hybrid
收录类别	SCI-E
WOS记录号	WOS:000491604300028
WOS关键词	GENE
WOS类目	Agriculture, Dairy & Animal Science
WOS研究方向	Agriculture
EI主题词	2019-10-01
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/310219
作者单位	1.Inner Mongolia Agr Univ, Coll Food Sci & Engn, Key Lab Dairy Biotechnol & Bioengn, Minist Educ, 306 Zhao Wu Rd, Hohhot 010018, Inner Mongolia, Peoples R China; 2.Camel Res Inst Inner Mongolia, Alashan 737300, Inner Mongolia, Peoples R China; 3.Chinese Acad Sci, Biomed Big Data Ctr, CAS MPG Partner Inst Computat Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Guo Fucheng,Si Rendalai,He Jing,et al. Comprehensive transcriptome analysis of adipose tissue in the Bactrian camel reveals fore hump has more specific physiological functions in immune and endocrine systems[J],2019,228:195-200.
APA	Guo Fucheng.,Si Rendalai.,He Jing.,Yuan Liyun.,Hai Le.,...&Ji Rimutu.(2019).Comprehensive transcriptome analysis of adipose tissue in the Bactrian camel reveals fore hump has more specific physiological functions in immune and endocrine systems.LIVESTOCK SCIENCE,228,195-200.
MLA	Guo Fucheng,et al."Comprehensive transcriptome analysis of adipose tissue in the Bactrian camel reveals fore hump has more specific physiological functions in immune and endocrine systems".LIVESTOCK SCIENCE 228(2019):195-200.