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Karst environments are characterized by distinctive landforms related to dissolution characteristics. Karst terrains, frequently underlain by cavernous carbonate and/or evaporite rocks, may induce ground instability problems. Impacts and problems associated with karst are rapidly increasing as development expands upon the karst prone areas. This has led to an escalation of karst-related environmental and engineering problems such as landslides developed on rock cuts/slopes weakened by karstification features. In the current work, the effects of karstification and sinkholes on the stability of the rock cuts/slopes along some selected desert highways were evaluated. These highways represent the most used highways in Egypt, connecting most of the Governorates. They represent the backbone of Egyptian transportation and commercial traffic. Finally, the most optimum mitigation/remediation methods were summarized to decrease and minimize the consequences of slope instability.