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The study area witnessed alternate paleoenvironmental and population events influenced by glacial/interglacial conditions. Paleosols, relict fluvial bodies, lacustrine carbonatic deposits, sand dunes, and other features underline the severely fluctuating activity of water resources. The study region (SW Libya) provides two different data sets: (1) two stratified, dated, Middle Stone Age/Aterian sites; and (2) hundreds of surface lithic scatters rarely associated with paleoenvironmental proxies. Early/Middle Pleistocene human occupation is presumable, but the bulk of evidence is from the late Middle/Late Pleistocene. Productive environments possibly housed human groups with a Late Acheulean technology during MIS 7. Most of the MSA evidences are barely diagnostic from a techno-typological point of view. Exceptions are made for scanty but precise similarities with sub-Saharan early MSA finds, suggesting the presence of modern humans in MIS 6, and for the Aterian, an example of MIS 4 arid landscape adaptation. Although MIS 3/2 post-Aterian human presence is not demonstrable, signs of a generalized LSA technology are recognizable in the Messak, where stony raw materials could have attracted task-specific temporary occupants.