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In this study, we present a brief review on the existing approaches for optical turbulence estimation in various layers of the Earth's atmosphere. The advantages and disadvantages of these approaches are also discussed. An alternative approach, based on mesoscale modeling with parameterized turbulence, is proposed and tested for the simulation of refractive index structure parameter (C-n(2)) in the atmospheric boundary layer. The impacts of a few atmospheric flow phenomena (e.g., low-level jets, island wake vortices, gravity waves) on optical turbulence are discussed. Consideration of diverse geographic settings (e.g., flat terrain, coastal region, ocean islands) makes this study distinct.