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DOI | 10.1016/j.forsciint.2012.11.015 |
Simultaneous determination of 5 psychotropic drugs of various types in an autopsy case of acute multiple drug poisoning | |
Sasaki, Chizuko1; Shinozuka, Tatsuo2; Murakami, Chikako1; Irie, Wataru1; Maeda, Kazuho1; Watanabe, Toshimasa1; Nakamaru, Naomi1; Furukawa, Masataka1; Nakamura, Shigeki1; Kurihara, Katsuyoshi1 | |
通讯作者 | Sasaki, Chizuko |
会议名称 | 50th Annual Meeting of the International-Association-of-Forensic-Toxicologists (TIAFT) / Joint Meeting of the 31st Annual Meeting of Japanese-Association-of-Forensic-Toxicology (JAFT) / 96th Annual Meeting of Japanese-Society-of-Legal-Medicine (JSLM) |
会议日期 | JUN 03-08, 2012 |
会议地点 | Hamamatsu, JAPAN |
英文摘要 | We attempted the simultaneous determination of 5 drugs, mirtazapine, sertraline, chlorpromazine, amoxapine and zolpidem, detected in a gas chromatography-mass spectrometry screening test in an autopsy case. The solid-phase extraction of the analytes from biological samples was achieved using Oasis (R) HLB cartridges (Waters, Milford, MA, USA). Gas chromatography was performed on a HP-5MS fused silica capillary column (30 m x 0.25 mm i.d., 0.25 mu m film thickness, Agilent Technologies). The mass spectrometer was operated with an electron energy of 70 eV in electron impact mode. The qualitative and quantitative analyses were performed in full-scan mode and the selected ion monitoring mode, respectively. The total ion chromatogram showed good separation of these drugs. Linear graphs were obtained with good correlation coefficients for these drugs from 0.001 to 2.0 mu g/mL (r(2) = 0.9909-0.9986) using imipramine-d6 as an internal standard. The recoveries of these drugs were found to be 62.8-88.0% in spiked whole blood. Mirtazapine, sertraline, chlorpromazine, amoxapine and zolpidem were found in post-mortem samples of the deceased at concentrations of 2.67, 0.07, 0.25, 0.32 and 0.68 mg/mL, respectively. The concentration of mirtazapine was within the lethal level and those of amoxapine and zolpidem were within the toxic level. We diagnosed that the cause of death was acute multiple drug poisoning. The simple and practical procedure used in this study is useful for the simultaneous determination of psychotropic drugs of various types in post-mortem biological samples. (c) 2012 Elsevier Ireland Ltd. All rights reserved. |
英文关键词 | Simultaneous determination GC-MS Mirtazapine Multiple drug poisoning Psychotropic drugs Solid-phase extraction |
来源出版物 | FORENSIC SCIENCE INTERNATIONAL |
ISSN | 0379-0738 |
EISSN | 1872-6283 |
出版年 | 2013 |
卷号 | 227 |
期号 | 1-3 |
页码 | 90-94 |
出版者 | ELSEVIER IRELAND LTD |
类型 | Article;Proceedings Paper |
语种 | 英语 |
国家 | Japan |
收录类别 | SCI-E ; CPCI-S |
WOS记录号 | WOS:000316793300018 |
WOS关键词 | AMOXAPINE OVERDOSE |
WOS类目 | Medicine, Legal |
WOS研究方向 | Legal Medicine |
资源类型 | 会议论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/301783 |
作者单位 | 1.Kitasato Univ, Sch Med, Dept Legal Med, Minami Ku, Sagamihara, Kanagawa 228, Japan; 2.Yokohama Coll Pharm, Dept Pathophysiol, Totsuka Ku, Yokohama, Kanagawa, Japan |
推荐引用方式 GB/T 7714 | Sasaki, Chizuko,Shinozuka, Tatsuo,Murakami, Chikako,et al. Simultaneous determination of 5 psychotropic drugs of various types in an autopsy case of acute multiple drug poisoning[C]:ELSEVIER IRELAND LTD,2013:90-94. |
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