Arid
DOI10.1016/j.chroma.2007.10.052
Trace level determination of beta-blockers in waste waters by highly selective molecularly imprinted polymers extraction followed by liquid chromatography-quadrupole-linear ion trap mass spectrometry
Gros, Meritxell1; Pizzolato, Tania-Mara2; Petrovic, Mira1,3; Lopez de Alda, Maria Jose1; Barcelo, Damia1
通讯作者Pizzolato, Tania-Mara
会议名称31st International Symposium on High Performance Liquid Phase Separations and Related Techniques
会议日期JUN 17-21, 2007
会议地点Ghent, BELGIUM
英文摘要

This paper describes the development of an analytical methodology to determine eight beta-blockers in waste waters using molecularly imprinted polymers (MIPs) as extraction and pre-concentration material, followed by liquid chromatography-quadrupole-linear ion trap mass spectrometry (LC-QqLIT MS). The advantages offered by MIPs, in terms of selectivity and specificity, were compared with the most commonly polymeric materials used (the lipophitic-hydrophilic balanced Oasis (R) HLB cartridges). Even though recoveries achieved with both sorbents were similar, ranging from 50 to 110% for sewage treatment plant (STP) effluent and 40-110 for STP influent, respectively, MIPs provided lower method detection limits than oasis (R) HLB, due to their specificity for target analytes and closely related analogues. Method detection limits (MDL) achieved using MIPs ranged from 0.2 to 6.4 ng/L for STP effluent and from 0.4 to 6.5 ng/L for STP influent. To highlight the advantages of MIPs against conventional polymeric cartridges, a detailed matrix effects study as well as cross reactivity tests were performed. For the latter purpose, the extraction efficiency of some pharmaceuticals and pesticides belonging to different therapeutic classes was assessed. LC-QqLIT MS, used for quantification and confirmation, proved to be a powerful analytical tool, as instrumental detection limits (IDL) achieved ranged from 0.2 to 2.7 pg injected (in multiple reaction monitoring mode (MRM)). In addition the inclusion of high sensitive MS/MS scans for each compound when working in Information Dependent Acquisition mode (IDA) provided extra confirmation for unequivocal identification of target compounds in complex environmental matrices. (c) 2007 Elsevier B.V. All rights reserved.


英文关键词molecularly imprinted polymers (MIP) beta-blockers waste water analysis liquid chromatography-quadrupole-linear ion trap (QqLIT)
来源出版物JOURNAL OF CHROMATOGRAPHY A
ISSN0021-9673
EISSN1873-3778
出版年2008
卷号1189
期号1-2
页码374-384
出版者ELSEVIER SCIENCE BV
类型Article;Proceedings Paper
语种英语
国家Spain;Brazil
收录类别SCI-E ; CPCI-S
WOS记录号WOS:000255698000037
WOS关键词SOLID-PHASE EXTRACTION ; RECEPTOR BLOCKING-AGENTS ; LC-MS ANALYSIS ; ENVIRONMENTAL-SAMPLES ; RIVER WATER ; BASIC PHARMACEUTICALS ; THERAPEUTIC CLASSES ; TREATMENT PLANTS ; NATURAL-WATERS ; SURFACE-WATER
WOS类目Biochemical Research Methods ; Chemistry, Analytical
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
资源类型会议论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/297202
作者单位1.CSIC, IIQAB, Dept Environm Chem, ES-08034 Barcelona, Spain;
2.Univ Fed Rio Grande do Sul, Inst Quim, BR-9500 Porto Alegre, RS, Brazil;
3.ICREA, Barcelona 80010, Spain
推荐引用方式
GB/T 7714
Gros, Meritxell,Pizzolato, Tania-Mara,Petrovic, Mira,et al. Trace level determination of beta-blockers in waste waters by highly selective molecularly imprinted polymers extraction followed by liquid chromatography-quadrupole-linear ion trap mass spectrometry[C]:ELSEVIER SCIENCE BV,2008:374-384.
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