Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1016/j.chroma.2007.10.052 |
Trace level determination of beta-blockers in waste waters by highly selective molecularly imprinted polymers extraction followed by liquid chromatography-quadrupole-linear ion trap mass spectrometry | |
Gros, Meritxell1; Pizzolato, Tania-Mara2; Petrovic, Mira1,3; Lopez de Alda, Maria Jose1; Barcelo, Damia1 | |
通讯作者 | Pizzolato, Tania-Mara |
会议名称 | 31st International Symposium on High Performance Liquid Phase Separations and Related Techniques |
会议日期 | JUN 17-21, 2007 |
会议地点 | Ghent, BELGIUM |
英文摘要 | This paper describes the development of an analytical methodology to determine eight beta-blockers in waste waters using molecularly imprinted polymers (MIPs) as extraction and pre-concentration material, followed by liquid chromatography-quadrupole-linear ion trap mass spectrometry (LC-QqLIT MS). The advantages offered by MIPs, in terms of selectivity and specificity, were compared with the most commonly polymeric materials used (the lipophitic-hydrophilic balanced Oasis (R) HLB cartridges). Even though recoveries achieved with both sorbents were similar, ranging from 50 to 110% for sewage treatment plant (STP) effluent and 40-110 for STP influent, respectively, MIPs provided lower method detection limits than oasis (R) HLB, due to their specificity for target analytes and closely related analogues. Method detection limits (MDL) achieved using MIPs ranged from 0.2 to 6.4 ng/L for STP effluent and from 0.4 to 6.5 ng/L for STP influent. To highlight the advantages of MIPs against conventional polymeric cartridges, a detailed matrix effects study as well as cross reactivity tests were performed. For the latter purpose, the extraction efficiency of some pharmaceuticals and pesticides belonging to different therapeutic classes was assessed. LC-QqLIT MS, used for quantification and confirmation, proved to be a powerful analytical tool, as instrumental detection limits (IDL) achieved ranged from 0.2 to 2.7 pg injected (in multiple reaction monitoring mode (MRM)). In addition the inclusion of high sensitive MS/MS scans for each compound when working in Information Dependent Acquisition mode (IDA) provided extra confirmation for unequivocal identification of target compounds in complex environmental matrices. (c) 2007 Elsevier B.V. All rights reserved. |
英文关键词 | molecularly imprinted polymers (MIP) beta-blockers waste water analysis liquid chromatography-quadrupole-linear ion trap (QqLIT) |
来源出版物 | JOURNAL OF CHROMATOGRAPHY A |
ISSN | 0021-9673 |
EISSN | 1873-3778 |
出版年 | 2008 |
卷号 | 1189 |
期号 | 1-2 |
页码 | 374-384 |
出版者 | ELSEVIER SCIENCE BV |
类型 | Article;Proceedings Paper |
语种 | 英语 |
国家 | Spain;Brazil |
收录类别 | SCI-E ; CPCI-S |
WOS记录号 | WOS:000255698000037 |
WOS关键词 | SOLID-PHASE EXTRACTION ; RECEPTOR BLOCKING-AGENTS ; LC-MS ANALYSIS ; ENVIRONMENTAL-SAMPLES ; RIVER WATER ; BASIC PHARMACEUTICALS ; THERAPEUTIC CLASSES ; TREATMENT PLANTS ; NATURAL-WATERS ; SURFACE-WATER |
WOS类目 | Biochemical Research Methods ; Chemistry, Analytical |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
资源类型 | 会议论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/297202 |
作者单位 | 1.CSIC, IIQAB, Dept Environm Chem, ES-08034 Barcelona, Spain; 2.Univ Fed Rio Grande do Sul, Inst Quim, BR-9500 Porto Alegre, RS, Brazil; 3.ICREA, Barcelona 80010, Spain |
推荐引用方式 GB/T 7714 | Gros, Meritxell,Pizzolato, Tania-Mara,Petrovic, Mira,et al. Trace level determination of beta-blockers in waste waters by highly selective molecularly imprinted polymers extraction followed by liquid chromatography-quadrupole-linear ion trap mass spectrometry[C]:ELSEVIER SCIENCE BV,2008:374-384. |
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