Arid
DOI10.1139/O07-057
Histone H3K4 demethylases are essential in development and differentiation
Benevolenskaya, Elizaveta V.
通讯作者Benevolenskaya, Elizaveta V.
会议名称28th International West Coast Chromatin Chromosomes Conference
会议日期DEC 14-17, 2006
会议地点Pacific Grove, CA
英文摘要

Lysine histone methylation is one of the most robust epigenetic marks and is essential for the regulation of multiple cellular processes. The methylation of Lys4 of histone H3 seems to be of particular significance. It is associated with active regions of the genome, and in Drosophila it is catalyzed by trithorax-group proteins that have become paradigms of developmental regulators at the level of chromatin. Like other histone methylation events, H3K4 methylation was considered irreversible until the identification of a large number of histone demethylases indicated that demethylation events play an important role in histone modification dynamics. However, the described demethylases had no strictly assigned biological functions and the identity of the histone demethylases that would contribute to the epigenetic changes specifying certain biological processes was unknown. Recently, several groups presented evidence that a family of 4 JmjC domain proteins results in the global changes of histone demethylation, and in elegant studies using model organisms, they demonstrated the importance of this family of histone demethylases in cell fate determination. All 4 proteins possess the demethylase activity specific to H3K4 and belong to the poorly described JARID1 protein family.


英文关键词JARID1 histone methylation JmjC domain H3K4me3
来源出版物BIOCHEMISTRY AND CELL BIOLOGY
ISSN0829-8211
EISSN1208-6002
出版年2007
卷号85
期号4
页码435-443
出版者CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
类型Article;Proceedings Paper
语种英语
国家USA
收录类别SCI-E ; CPCI-S
WOS记录号WOS:000249428900005
WOS关键词LINKED MENTAL-RETARDATION ; EMBRYONIC STEM-CELLS ; RETINOBLASTOMA-BINDING PROTEIN-2 ; LITTLE-IMAGINAL-DISCS ; TRANSCRIPTIONAL REGULATION ; ANDROGEN-RECEPTOR ; ARID PROTEINS ; BREAST-CANCER ; ACTIVE GENES ; TARGET GENES
WOS类目Biochemistry & Molecular Biology ; Cell Biology
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
资源类型会议论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/296399
作者单位(1)Univ Illinois, Dept Biochem & Mol Genet, Chicago, IL 60607 USA
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Benevolenskaya, Elizaveta V.. Histone H3K4 demethylases are essential in development and differentiation[C]:CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS,2007:435-443.
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