干旱区生态环境知识资源中心(Arid): Interference of Stress on Physostigmine Pretreatment Against Soman Intoxication in Guinea Pigs.

Arid

报告编号	ADA436051
	Interference of Stress on Physostigmine Pretreatment Against Soman Intoxication in Guinea Pigs.
	Philippens, I. H; Joosen, M. J; Groen, B; Vanwersch, R. A; Busker, R. W.
英文摘要	During research efforts towards finding effective drugs are performed in a standard laboratory situation. However, in a more realistic situation other factors may interfere with the treatment regime. There is growing evidence that stress occurring during military operations can impair the efficacy and appearance of side effects of medical treatment. It is known that stress can change the kinetics of the pretreatment (1) and, therefore, affect the protective ratio and evoke the appearance of side effects. During operation Desert Storm soldiers were given pyridostigmine (PYR) tablets against intoxication with acetylcholinesterase (AChE) inhibitors. The employed dose of PYR was expected not to show undesirable cholinergic effects. Nevertheless, peripheral and central side effects were recorded (2). These effects could be the result of stress. First of all, stress itself could be an important factor. It induces prolonged corticosterone secretion that leads to a reduction of hippocampal corticosteroid receptors, which affects other transmitter systems, such as acetylcholine (3). Secondly, stress enhances the passage across the blood-brain barrier (1). In operation Desert Storm nine cases of PYR self- poisoning were encountered. These individuals only suffered from peripheral cholinergic symptoms, whereas no effects on the central nervous system were observed (4). This supports the idea that a combination of many factors including stress plays a role in the appearance of side effects.
英文关键词	Stress(Physiology) Signs and symptoms Medical services Gd agent Intoxication Physostigmine Military operations Ratios Brain Army personnel Acetylcholinesterase Central nervous system Pyridines Cholinergic nerves Blood volume
出版年	2002
语种	英语
国家	Netherlands
URL	http://r.cnki.net/KCMS/detail/detail.aspx?DbCode=KJBG&dbname=KJBGW&filename=59facd1c31c97d1d549b7cd4
来源机构	Non Paid ADAS
资源类型	科技报告
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/273052
推荐引用方式 GB/T 7714	Philippens, I. H,Joosen, M. J,Groen, B,et al. Interference of Stress on Physostigmine Pretreatment Against Soman Intoxication in Guinea Pigs.,2002.