干旱区生态环境知识资源中心(Arid): 04-ERD-052-Final Report

Arid

DOI	10.2172/902387
报告编号	UCRL-TR-228361
来源ID	OSTI_ID: 902387
	04-ERD-052-Final Report
	Loots, G G; Ovcharenko, I; Collette, N; Babu, P; Chang, J; Stubbs, L; Lu, X; Pennachio, C; Harland, R M
英文摘要	Generating the sequence of the human genome represents a colossal achievement for science and mankind. The technical use for the human genome project information holds great promise to cure disease, prevent bioterror threats, as well as to learn about human origins. Yet converting the sequence data into biological meaningful information has not been immediately obvious, and we are still in the preliminary stages of understanding how the genome is organized, what are the functional building blocks and how do these sequences mediate complex biological processes. The overarching goal of this program was to develop novel methods and high throughput strategies for determining the functions of ''anonymous'' human genes that are evolutionarily deeply conserved in other vertebrates. We coupled analytical tool development and computational predictions regarding gene function with novel high throughput experimental strategies and tested biological predictions in the laboratory. The tools required for comparative genomic data-mining are fundamentally the same whether they are applied to scientific studies of related microbes or the search for functions of novel human genes. For this reason the tools, conceptual framework and the coupled informatics-experimental biology paradigm we developed in this LDRD has many potential scientific applications relevant to LLNL multidisciplinary research in bio-defense, bioengineering, bionanosciences and microbial and environmental genomics.
出版年	2007
报告类型	Technical Report
语种	英语
国家	美国
来源学科分类	59 BASIC BIOLOGICAL SCIENCES ; BIOLOGY ; FUNCTIONALS ; GENES ; LAWRENCE LIVERMORE NATIONAL LABORATORY ; VERTEBRATES
URL	http://www.osti.gov/scitech/servlets/purl/902387
资源类型	科技报告
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/269335
推荐引用方式 GB/T 7714	Loots, G G,Ovcharenko, I,Collette, N,et al. 04-ERD-052-Final Report,2007.