干旱区生态环境知识资源中心(Arid): MANAGEMENT PRE-START REVIEW FINAL REPORT FOR THE BIOSAFETY LEVEL 3 (BSL-3) FACILITY (B368) LAWRENCE LIVERMORE NATIONAL LABORATORY

Arid

DOI	10.2172/898446
报告编号	UCRL-TR-223233
来源ID	OSTI_ID: 898446
	MANAGEMENT PRE-START REVIEW FINAL REPORT FOR THE BIOSAFETY LEVEL 3 (BSL-3) FACILITY (B368) LAWRENCE LIVERMORE NATIONAL LABORATORY
	Hull, R; O'brien, J; Owens, T; Salvo, V; Sassone, D; Tuholski, S J; Tsan, S
英文摘要	A Lawrence Livermore National Laboratory (LLNL) Management Pre-Start Review (MPR) Team was formed to independently verify the operational readiness of Building 368 (B368) Biosafety Level III (BSL-3) Facility to conduct research with biological pathogens and toxins including those considered Select Agents. Review objectives and criteria were developed from the DOE/NNSA and LLNL requirements. These were provided in the Implementation Plan for the Biosafety Level III (BSL-3) Facility Management Pre-Start Review (BSL-3 MPR) at Lawrence Livermore National Laboratory that was reviewed and approved by DOE/NNSA-LSO. The formal part of the LLNL MPR for the BSL-3 Facility was begun in August of 2005 but work on the MPR was stopped in October of 2005 due to the need for LLNL to reassess organizational and operational controls and respond to Centers for Disease Control and Prevention inquiries related to a shipping incident involving select agents. The MPR was restarted in mid-June of 2006. Preliminary facility tours and familiarization with project documents took place in June of 2005. The Independent Management Review Team consists of seven members led by a Team Leader with expertise in management, operations, and safety basis experience with biosafety laboratories. Other team members have expertise in electrical engineering, security, environmental/waste management/regulatory compliance, biosafety/industrial hygiene/medical, structural engineering, and mechanical engineering. The MPR Team reviewed various documents, including authorization basis, safety, emergency preparedness, and various operations, configuration, and management plans. They also reviewed building plans, equipment repair/maintenance documents, training records, and many standard operating procedures. The MPR resulted in three Pre-Start Findings, one Post-Start/Critical Finding, and four observations which are shown on Tables 1, 2, and 3, respectively. Based upon this review the Team feels that the B368 Facility can be operated safely provided the Pre-Start Findings are satisfactorily closed. The Team therefore seen no reason not to expeditiously proceed towards the startup of this facility in accordance with the processes defined in DOE Order 425.1C, and the LLNL ES&H Manual. Details of the MPR Team evaluations of the various Subject (functional) Areas of the review are contained in the completed MPR Assessment Forms in Appendix A. Findings are described in completed MPR Deficiency Forms in Appendix B. The format of these forms is consistent with DOE-STD-3006.
出版年	2006
报告类型	Technical Report
语种	英语
国家	美国
来源学科分类	59 BASIC BIOLOGICAL SCIENCES ; COMPLIANCE ; CONFIGURATION ; DISEASES ; ELECTRICAL ENGINEERING ; IMPLEMENTATION ; LAWRENCE LIVERMORE NATIONAL LABORATORY ; MANAGEMENT ; MECHANICAL ENGINEERING ; PATHOGENS ; SAFETY ; SECURITY ; TOXINS ; TRAINING
URL	http://www.osti.gov/scitech/servlets/purl/898446
资源类型	科技报告
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/269218
推荐引用方式 GB/T 7714	Hull, R,O'brien, J,Owens, T,et al. MANAGEMENT PRE-START REVIEW FINAL REPORT FOR THE BIOSAFETY LEVEL 3 (BSL-3) FACILITY (B368) LAWRENCE LIVERMORE NATIONAL LABORATORY,2006.