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| Leaflet Material Selection for Aortic Valve Repair | |
| Abessi;Ovais | |
| 出版年 | 2013 |
| 英文摘要 | Leaflet replacement in aortic valve repair (AVr) is associated with increased long-term repair failure. Hemodynamic performance and mechanical stress levels were investigated after porcine AVr with 5 types of clinically relevant replacement materials to ascertain which material(s) would be best suited for repair. Porcine aortic roots with intact aortic valves were placed in a left-heart simulator mounted with a high-speed camera for baseline valve assessment. Then, the non-coronary leaflet was excised and replaced with autologous porcine pericardium (APP), glutaraldehyde-fixed bovine pericardial patch (BPP; Synovis™), extracellular matrix scaffold (CorMatrix™), or collagen-impregnated Dacron (HEMASHIELD™). Hemodynamic parameters were measured over a range of cardiac outputs (2.5–6.5L/min) post-repair. Material properties of the above materials along with St. Jude Medical™ Pericardial Patch with EnCapTM Technology (SJM) were determined using pressurization experiments. Finite element models of the aortic valve and root complex were then constructed to verify the hemodynamic characteristics and determine leaflet stress levels. This study demonstrates that APP and SJM have the closest profiles to normal aortic valves; therefore, use of either replacement material may be best suited. Increased stresses found in BPP, HEMASHIELD™, and CorMatrix™ groups may be associated with late repair failure. |
| 英文关键词 | AI: aortic insufficiency APP APP: autologous porcine pericardium AS: aortic stenosis AV: aortic valve AVR: aortic valve replacement BPP: bovine pericardial patch CT-A: computed tomography angiography FE: finite element GOA: geometric orifice area LVOT: left-ventricular outflow tract LVW: left ventricular work MRI: magnetic resonance imaging STJ: sino-tubular junction SJM: St-Jude Medical TEE: transesophageal echography VC: valve closing speed VO: valve opening speed VSC: valve slow closing speed |
| 语种 | 英语 |
| URL | http://hdl.handle.net/10393/30191 |
| 资源类型 | 学位论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/247654 |
| 推荐引用方式 GB/T 7714 | Abessi;Ovais. Leaflet Material Selection for Aortic Valve Repair[D],2013. |
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