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| Pharmacogenetic Inhibition of the Subcoeruleus Region Influences REM Sleep and Cataplexy in Narcoleptic Mice | |
| Sanghera;Karan Paul | |
| 出版年 | 2013 |
| 英文摘要 | Introduction: Cataplexy - the sudden involuntary loss of skeletal muscle tone – is a defining feature of narcolepsy. The current study aimed to determine if cataplexy is influenced by direct manipulation of REM sleep circuitry. We did this by pharmacogenetically inhibiting the REM sleep center, subcoeruleus (Sub-C). Methods: Inhibitory DREADD (hM4D-Gi) was bilaterally targeted to the Sub-C in hypocretin knockout mice (n=7). Intraperitoneal administration of clozapine-n-oxide was used to inhibit Sub-C cells expressing hM4D-Gi. Electrophysiological and behavioral criteria were used to characterize cataplexy and REM sleep. Results: Sub-C inhibition increased REM sleep and cataplexy amounts (p<0.05). Sub-C inhibition increased time spent in cataplexy amounts by increasing the number of cataplexy attacks (p<0.05). This intervention triggered increases in basal muscle tone during REM sleep, but had negligible effects on muscle tone during cataplexy (p>0.05). Conclusion: Pharmacogenetic manipulation of the Sub-C suggest that REM sleep and cataplexy are mediate by similar neural mechanism. |
| 英文关键词 | Sleep REM Sleep Subcoeruleus Cataplexy Narcolepsy 0317 |
| 语种 | 英语 |
| URL | http://hdl.handle.net/1807/42909 |
| 资源类型 | 学位论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/247555 |
| 推荐引用方式 GB/T 7714 | Sanghera;Karan Paul. Pharmacogenetic Inhibition of the Subcoeruleus Region Influences REM Sleep and Cataplexy in Narcoleptic Mice[D],2013. |
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