Knowledge Resource Center for Ecological Environment in Arid Area
| Ventral Tegmental Area GABAA Receptors Mediate the Change from a Drug-naive to an Opiate- or Ethanol-deprived Motivational State | |
| Ting-A-Kee;Ryan Anthony | |
| 出版年 | 2012 |
| 英文摘要 | A crucial question in drug addiction research concerns whether the varying reports of dopamine-independent and dopamine-dependent motivation can be integrated. According to one theory, the prior drug history of a subject — that is to say, whether they have received minimal or chronic drug exposure — determines whether opiate motivation is dependent upon the brainstem tegmental pedunculopontine nucleus (TPP) or dopamine neurotransmission. The biological analogue of this change is thought to be a switch in the signalling properties (from hyperpolarizing to depolarizing) of ventral tegmental area (VTA) gamma-aminobutyric acid subtype-A (GABAA) receptors. In this thesis, I demonstrate that the mechanisms underlying opiate motivation can be selected artificially by manipulating the signalling properties of VTA GABAA receptors, irrespective of the past drug history of the subject. Furthermore, I suggest that these same VTA GABAA receptors also play a similar role in controlling ethanol motivation. Indeed, the mechanisms underlying ethanol motivation can be doubly dissociated in a manner similar to that observed with opiates. However, whereas opiate motivation is TPP-dependent in the drug-naive state, I found that ethanol motivation was dependent on dopamine neurotransmission (via the D2 receptor) in drug-naive animals. Conversely, ethanol motivation was TPP-dependent in ethanol-deprived mice (as opposed to opiate motivation being dopamine-dependent in opiate-deprived animals). These effects are consistent with a VTA GABAA receptor switching mechanism identical to the one seen in the case of opiate motivation. |
| 英文关键词 | Motivation Morphine Ethanol Ventral tegmental area 0384 |
| 语种 | 英语 |
| URL | http://hdl.handle.net/1807/32827 |
| 资源类型 | 学位论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/246355 |
| 推荐引用方式 GB/T 7714 | Ting-A-Kee;Ryan Anthony. Ventral Tegmental Area GABAA Receptors Mediate the Change from a Drug-naive to an Opiate- or Ethanol-deprived Motivational State[D],2012. |
| 条目包含的文件 | 条目无相关文件。 | |||||
| 个性服务 |
| 推荐该条目 |
| 保存到收藏夹 |
| 导出为Endnote文件 |
| 谷歌学术 |
| 谷歌学术中相似的文章 |
| [Ting-A-Kee;Ryan Anthony]的文章 |
| 百度学术 |
| 百度学术中相似的文章 |
| [Ting-A-Kee;Ryan Anthony]的文章 |
| 必应学术 |
| 必应学术中相似的文章 |
| [Ting-A-Kee;Ryan Anthony]的文章 |
| 相关权益政策 |
| 暂无数据 |
| 收藏/分享 |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
