干旱区生态环境知识资源中心(Arid): RRLC-MS/MS同时测定食品接触材料中9种双酚类化合物迁移量

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	RRLC-MS/MS同时测定食品接触材料中9种双酚类化合物迁移量
其他题名	Simultaneous Determination of the Migration of 9Bisphenols in Food Contact Material by RRLC-MS/MS
	熊小婷; 王继才; 王海洋; 黄日林; 陈意光; 李燕飞; 谭建华; 李慧勇; 席绍峰
来源期刊	质谱学报
ISSN	1004-2997
出版年	2019
卷号	40 期号:2 页码:151-158
中文摘要	建立了高分离度快速液相色谱-串联质谱(RRLC-MS/MS)法同时测定食品接触材料中9种双酚类化合物的迁移量。样品经不同类型食品模拟物浸泡后,用Oasis HLB固相萃取柱净化,Agilent poroshell 120SB-C18柱(2.1mm100mm2.7mum)分离,以甲醇和0.1mmol/L乙酸铵水溶液为流动相进行梯度洗脱,在电喷雾负离子模式(ESI-)和多反应监测(MRM)模式下进行分析。结果表明,在优化的实验条件下,9种双酚类化合物的线性关系良好,相关系数(R2)均大于0.99,检出限为0.01~0.2 mug/kg,定量限为0.05~1.0mug/kg,在低、中、高3个加标水平下的回收率为76.9%~113.1%,相对标准偏差为1.9%~6.7%。本方法灵敏、准确、可靠、快速,能满足食品接触材料中9种双酚类化合物迁移量的检测需求。
英文摘要	A method of rapid resolution liquid chromatography-tandem mass spectrometry(RRLC-MS/MS)was developed for the simultaneous determination of the migration of 9bisphenols(bisphenol A,bisphenol F,bisphenol S,bisphenol B,bisphenol E,tet-rabromobisphenol A,hexafluorobisphenol A,bisphenol AP,bisphenol BP)in food contact materials.Different types of food simulants (4% acetic acid,50% ethanol, isooctane)were used for migration test to simulate different types of food,such as acidic foods,alcoholic foods and oils.After the migration test,10mL of 4%acetic acid soaking solution were directly put in to solid phase extraction cartridge which had been pretreated, while 10mL of 50%ethanol or isooctane soaking solution were dried by nitrogen in the water bath of 45℃,re-dissolved in 2mL methanol,and fixed to 10mL by water before purification.An Oasis HLB solid phase extraction cartridge (200 mg/6mL)was applied for purification.The separation was performed on an Agilent poroshell 120SB-C18column(2.1mm100mm2.7mum)by using methanol and 0.1 mmol/L ammonium acetate as mobile phases with gradient elution.The electrospray ionization source in negative ion(ESI-)mode was used for the determination of the 9 bisphenols under the multiple reaction monitoring(MRM)mode.The results verified that,under the optimized experimental conditions,satisfactory linearities of the 9 bisphenols were obtained with correlation coefficients(R2)higher than 0.99.The limits of detection(LOD)and quantitation(LOQ)of the 9bisphenols were in the range of 0.01-0.2mug/kg and 0.05-1.0mug/kg,respectively.The average recoveries of 9bisphenols ranged from 76.9%to 113.1% at three spiking levels,and the relative standard deviations(RSDs)were between 1.9%and 6.7%.The method is sensitive,accurate, reliable and rapid,and can fully meet the requirements for the simultaneous determination of migration of the 9bisphenols in food contact materials and products.60samples of different types of food contact materials and products,including polycarbonate buckets, baby bottles,cups,food cans and food metal covers,were analyzed by the method. The results showed that bisphenol A and bisphenol F were found in food simulant soaking solution of 4and 1food metal covers,respectively.The test results indicate that bisphenols may be present in certain food contact materials and products,and also can be transferred to food in the process of product use.
中文关键词	高分离度快速液相色谱-串联质谱(RRLC-MS/MS) ; 食品接触材料 ; 双酚类化合物 ; 迁移量
英文关键词	rapid resolution liquid chromatography-tandem mass spectrometry(RRLCMS/ MS) food contact materials bisphenols migration
语种	中文
国家	中国
收录类别	CSCD
WOS类目	CHEMISTRY ANALYTICAL
WOS研究方向	Chemistry
CSCD记录号	CSCD:6509845
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/239718
作者单位	广州质量监督检测研究院,国家包装产品质量监督检验中心(广州), 广州, 广东 511447, 中国
推荐引用方式 GB/T 7714	熊小婷,王继才,王海洋,等. RRLC-MS/MS同时测定食品接触材料中9种双酚类化合物迁移量[J],2019,40(2):151-158.
APA	熊小婷.,王继才.,王海洋.,黄日林.,陈意光.,...&席绍峰.(2019).RRLC-MS/MS同时测定食品接触材料中9种双酚类化合物迁移量.质谱学报,40(2),151-158.
MLA	熊小婷,et al."RRLC-MS/MS同时测定食品接触材料中9种双酚类化合物迁移量".质谱学报 40.2(2019):151-158.