干旱区生态环境知识资源中心(Arid): 利用1H-NMR比较管花肉苁蓉野生品和栽培品的化学成分组

Arid

	利用1H-NMR比较管花肉苁蓉野生品和栽培品的化学成分组
其他题名	Chemome comparison between cultivated and wild Cistanche tubulosa using 1H-NMR spectroscopy
	刘文静 1; 刘瑶 1; 宋青青 1; 颜昱 2; 赵云芳 1; 屠鹏飞 1; 李军 1; 宋月林 1
来源期刊	中国中药杂志
ISSN	1001-5302
出版年	2018
卷号	43 期号:17 页码:3506-3512
中文摘要	管花肉苁蓉素有沙漠人参之称,为著名补益类中药。为了缓解管花肉苁蓉的资源问题并有效保护野生资源,我国在新疆的南疆地区大力推广管花肉苁蓉的人工栽培,目前已取得了可喜的成果。该文利用1H-NMR技术能够全面提供定性和定量信息的优点,深入地比较管花肉苁蓉野生品和栽培品的化学成分组,以期为栽培品替代野生品使用的科学性提供直接证据。野生品和栽培品药材提取后,平行采集1H-NMR图谱;通过直观比较,发现2组图谱间相似度较高;通过与对照品及数据库(如HMDB,BMRB等)比对,从典型图谱中初步鉴定了28个化学成分;利用多元统计学手段比较野生品和栽培品的1H-NMR图谱,发现两组样品间并不存在显著差异。统计结果表明,从化学成分组成而言,管花肉苁蓉的野生品与栽培品相似度高,一定程度上证明栽培品可以替代野生品使用。同时,~1H-NMR技术能够反映中药提取物等复杂体系的定量化学成分组,在中药化学成分定性和定量分析领域具有较为广泛的应用前景。
英文摘要	As a famous tonic medicine,Cistanche tubulosa has been honored as " ginseng of the deserts" for centuries. Aiming to address the resource shortage as well as the wild resource protection towards this herbal medicine,wide cultivation has been achieved in the southern Xinjiang. Herein,in-depth chemome comparison was conducted between cultivated and wild plants using 1H-NMR spectroscopy that is capable of comprehensively providing qualitative and quantitative information of given complicated matrices. Multivariate statistical analysis was employed to process the dataset as well as to consolidate that the cultivated plants are comparable to those wild ones in term of chemome. 1H-NMR spectra of both wild and cultivated plants were acquired in parallel after extraction. Following direct overlaying,great similarity occurred between these two groups. A total of 28 compounds were tentatively identified by referring to authentic compounds together with those available databases,such as HMDB and BMRB. Following principal component analysis, none significant difference was observed between wild and cultivated groups. Above all,from the viewpoint of chemical profile,the cultivated plants were almost equal to the wild plants; therefore,the cultivated plants are able to take the load of wild plants in clinical usage. Moreover,~1H-NMR spectroscopy is a promising tool for chemical profiling traditional Chinese medicines because of the potential towards simultaneously exhibiting both quantitative and qualitative information for complicated matrices.
中文关键词	~1H-NMR技术 ; 管花肉苁蓉 ; 化学成分组 ; 野生品 ; 栽培品
英文关键词	~1H-NMR spectroscopy Cistanche tubulosa chemome wild resource cultivated plants
语种	中文
国家	中国
收录类别	CSCD
WOS类目	MEDICINE GENERAL INTERNAL
WOS研究方向	General & Internal Medicine
CSCD记录号	CSCD:6360697
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/238874
作者单位	1.北京中医药大学中药学院中药现代研究中心, 北京 100029, 中国; 2.北京中医药大学中药学院中药现代研究中心;;中央民族大学药学院中国少数民族传统医学研究院, ;;, ;;, 北京;;北京 100029;;100081, 中国
推荐引用方式 GB/T 7714	刘文静,刘瑶,宋青青,等. 利用1H-NMR比较管花肉苁蓉野生品和栽培品的化学成分组[J],2018,43(17):3506-3512.
APA	刘文静.,刘瑶.,宋青青.,颜昱.,赵云芳.,...&宋月林.(2018).利用1H-NMR比较管花肉苁蓉野生品和栽培品的化学成分组.中国中药杂志,43(17),3506-3512.
MLA	刘文静,et al."利用1H-NMR比较管花肉苁蓉野生品和栽培品的化学成分组".中国中药杂志 43.17(2018):3506-3512.