干旱区生态环境知识资源中心(Arid): 应用Y染色体SNP对新疆三个隔离人群遗传多样性的研究

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	应用Y染色体SNP对新疆三个隔离人群遗传多样性的研究
其他题名	A study of genetic diversity of three isolated populations in Xinjiang using Y-SNP
	刘树虎; 伊力哈木·乃扎木; 热比亚木·巴克; 布帕提玛穆·阿布都克热穆; 多力坤·买买提玉素甫
来源期刊	人类学学报
ISSN	1000-3193
出版年	2018
卷号	37 期号:1 页码:146-156
中文摘要	克里雅人、罗布人、刀郎人是生活在我国西部边疆沙漠腹地、人口稀少的隔离人群。基于对这三个隔离人群179人Y染色体全序列的测序和分型,得到每个个体Y染色体所有突变的SNP位点和隶属的单倍群,并对各单倍群类型和频率进行了分析。以探知三个隔离人群的Y染色体遗传结构和遗传多样性。通过研究结果表明:克里雅人群检出12个单倍群,高频单倍群有J2albl(25.64%), Rlalalb2a(20.51%), R2a(17.95%), Rlalalb2a2(15.38%);罗布人群检出16个单倍群,高频单倍群有J2a1(43.75%), J2a2(14.06%), R2(9.38%), Llc(7.81%);刀郎人群检出40个单倍群,高频单倍群有Rlblalal(9.21%), Rlalalb2ala(7.89%), Rlalalb2a2b(6.58%), C3c1(6.58%).三个隔离人群与维吾尔族、蒙古族、撒拉族亲缘关系较近;在单倍群类型和频率上与维吾尔族最接近且无显著性差异(f=0.833, p=0.367)。此外,三个隔离人群单倍群类型和频率显示明显的亚欧混合现象,经过长期基因融合使其具有中亚人群的典型特征,适用于法医遗传学。
英文摘要	The Keriyan, Lopnur and Dolan peoples are isolated populations with sparse numbers living in the western border desert of our country. By sequencing and typing the complete Y-chromosome of 179 individuals in these three isolated populations, all mutations and SNPs in the Y-chromosome and their corresponding haplotypes were obtained. Types and frequencies of each haplotype were analyzed to investigate genetic diversity and genetic structure in the three isolated populations. The results showed that 12 haplogroups were detected in the Keriyan with high frequencies of the J2albl (25.64%), Rlalalb2a (20.51%), R2a (17.95%) and Rlalalb2a2 (15.38%) groups. Sixteen haplogroups were noted in the Lopnur with the following frequencies: J2al (43.75%), J2a2 (14.06%), R2 (9.38%) and L1c (7.81%). Forty haplogroups were found in the Dolan, noting the following frequencies: Rlblalal (9.21%), Rlalalb2ala (7.89%), Rlalalb2a2b (6.58%) and C3cl (6.58%). These data show that these three isolated populations have a closer genetic relationship with the Uygur, Mongolian and Sala peoples. In particular, there are no significant differences in haplotype and frequency between the three isolated populations and Uygur (f=0.833,p=0.367). In addition, the genetic haplotypes and frequencies in the three isolated populations showed marked Eurasian mixing illustrating typical characteristics of Central Asian populations.
中文关键词	隔离人群 ; Y染色体 ; 单核苷酸多态性 ; 单倍群 ; 遗传多样性
英文关键词	Isolated population Y-chromosome SNP Haplogroup Genetic diversity
语种	中文
国家	中国
收录类别	CSCD
WOS类目	ANTHROPOLOGY
WOS研究方向	Anthropology
CSCD记录号	CSCD:6174010
来源机构	新疆大学
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/238044
作者单位	新疆大学生命科学与技术学院, 乌鲁木齐, 新疆 830046, 中国
推荐引用方式 GB/T 7714	刘树虎,伊力哈木·乃扎木,热比亚木·巴克,等. 应用Y染色体SNP对新疆三个隔离人群遗传多样性的研究[J]. 新疆大学,2018,37(1):146-156.
APA	刘树虎,伊力哈木·乃扎木,热比亚木·巴克,布帕提玛穆·阿布都克热穆,&多力坤·买买提玉素甫.(2018).应用Y染色体SNP对新疆三个隔离人群遗传多样性的研究.人类学学报,37(1),146-156.
MLA	刘树虎,et al."应用Y染色体SNP对新疆三个隔离人群遗传多样性的研究".人类学学报 37.1(2018):146-156.