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| 固相萃取-高效液相色谱-串联质谱法同时测定不同基质保健食品中10种减肥药物 | |
| 其他题名 | HPLC-MS/MS Simultaneous Determination of 10Diet Drugs in Health-Care Foods of Different Matrices with Solid Phase Extraction |
| 熊爽 | |
| 来源期刊 | 理化检验. B, 化学分册
 |
| ISSN | 1001-4020 |
| 出版年 | 2018 |
| 卷号 | 54期号:2页码:142-147 |
| 中文摘要 | 采用固相萃取-高效液相色谱-串联质谱法同时测定不同基质保健食品中10种减肥药物。保健食品样品采用甲醇超声提取,经Oasis HLB固相萃取柱净化,以Zorbax-SB-C_(18)色谱柱为分离柱,以不同体积比的10 mmol·L~(-1)乙酸铵-0.1%(体积分数)甲酸溶液和乙腈的混合液为流动相进行梯度洗脱,采用电喷雾正离子源多反应监测模式检测。10种减肥药物的质量浓度均在1.0~100.0 mug·L~(-1)内与其对应的峰面积呈线性关系,方法的检出限(3S/N)为1.2~3.8 mug· kg~(-1)。以空白样品为基体进行加标回收试验,所得回收率为79.5%~106%,测定值的相对标准偏差(n=6)为2.5%~9.7%。 |
| 英文摘要 | HPLC-MS/MS was applied to the simultaneous determination of 10 diet drugs in health-care foods of different matrices with solid phase extraction.The health-care food sample was extracted ultrasonically with methanol,and the extract was purified by Oasis HLB solid phase extraction column. Zorbax-SB-C_(18) chromatographic column was used as stationary phase,and the mixtures of 10 mmol·L~(-1) ammonium acetate-0.1% (phi)formic acid solution and acetonitrile mixed in different ratios were used as mobile phase in gradient elution. ESI~+ and multi-reactions monitor mode were adopted in MS/MS.Linear relationships between values of peak area and mass concentration of the 10 diet drugs were kept in the same range of 1.0-100.0 mug·L~(-1),with detection limits(3S/N)in the range of 1.2-3.8 mug·kg~(-1).On the base of blank sample,test for recovery was made by standard addition method.Values of recovery found were in the range of 79.5%-106%,with RSD’s(n=6)in the range of 2.5%-9.7%. |
| 中文关键词 | 高效液相色谱-串联质谱法 ; 减肥药物 ; 基质 ; 保健食品 ; 固相萃取 |
| 英文关键词 | HPLC-MS/MS diet drug matrix health-care food solid phase extraction |
| 语种 | 中文 |
| 国家 | 中国 |
| 收录类别 | CSCD |
| WOS类目 | CHEMISTRY ANALYTICAL |
| WOS研究方向 | Chemistry |
| CSCD记录号 | CSCD:6170442 |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/237907 |
| 作者单位 | 辽宁省分析科学研究院, 辽宁省标准化体系建设工程技术研究中心, 沈阳, 辽宁 110015, 中国 |
| 推荐引用方式 GB/T 7714 | 熊爽. 固相萃取-高效液相色谱-串联质谱法同时测定不同基质保健食品中10种减肥药物[J],2018,54(2):142-147. |
| APA | 熊爽.(2018).固相萃取-高效液相色谱-串联质谱法同时测定不同基质保健食品中10种减肥药物.理化检验. B, 化学分册,54(2),142-147. |
| MLA | 熊爽."固相萃取-高效液相色谱-串联质谱法同时测定不同基质保健食品中10种减肥药物".理化检验. B, 化学分册 54.2(2018):142-147. |
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