干旱区生态环境知识资源中心(Arid): 动物源性食品中56种兽药残留物的UPLC-MS/MS高通量分析

Arid

	动物源性食品中56种兽药残留物的UPLC-MS/MS高通量分析
其他题名	UPLC-MS/MS high-throughput detection of 56 veterinary drug residues in food products of animal origin
	王嘉琦; 马立利; 曹英华; 王建凤; 刘喆; 范筱京; 贾丽
来源期刊	分析试验室
ISSN	1000-0720
出版年	2018
卷号	37 期号:3 页码:306-310
中文摘要	建立了超高效液相色谱串联质谱法同时测定56种动物源性兽药残留物的分析方法。以乙腈-0.5%乙酸水溶液(85:15,V/V)为提取溶剂,采用固相萃取柱(Oasis PRiME HLB)进行样品净化,通过UPLC-MS/MS分析测定,基质曲线外标法定量。方法定量限为1.0 mug/kg(喹诺酮类)、1.5 mug/kg(糖皮质类)、10 mug/kg(磺胺类)、1.0 mug/kg(beta-受体激动剂类)。56种兽药残留物在牛肉、猪肉、鸡肉和奶等基质样品中回收率范围为63.2%~101.5%,基质标准工作曲线线性相关系数大于0.937,精密度RSD<15%(n=3)。方法适用于动物源性食品中兽药残留物的分析。
英文摘要	A method for simultaneous determination of 56 veterinary drug residues in food products of animal originwas established by UPLC-MS/MS.After extraction by the mixed solvent of acetonitrile and 0.5% acetic acid in water(85:15),the sample extracts were subjected to a cleanup procedure by using Oasis PRiME HLB column. The residue contentswas analyzed by UPLC-MS/MS, and the quantitative information was obtained bymatrix-matched calibration with external standard. The LOQs of 4-quinolones, glucocorticoid, sulfonamides and beta-agonist were determined to be 1.0, 1.5, 10 and 1.0 mug/kg, respectively. 56 veterinary drugs exhibited good linear relationship with correlation coefficient of 0.937 and RSD less than 15%(n=3). The recoveries of veterinary drugs in matrix including beef, pork, chicken and milk ranged from 63% to 101%. The method was quick and simple, and would be suitable for the detection of veterinary drug residues in food products of animal origin.
中文关键词	兽药 ; 超高效液相色谱串联质谱 ; 固相萃取柱Oasis PRiME HLB
英文关键词	Veterinary drug UPLC-MS/MS Oasis PRiME HLB Animal origin
语种	中文
国家	中国
收录类别	CSCD
WOS类目	ENGINEERING INDUSTRIAL
WOS研究方向	Engineering
CSCD记录号	CSCD:6191888
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/237513
作者单位	北京市理化分析测试中心, 北京 100089, 中国
推荐引用方式 GB/T 7714	王嘉琦,马立利,曹英华,等. 动物源性食品中56种兽药残留物的UPLC-MS/MS高通量分析[J],2018,37(3):306-310.
APA	王嘉琦.,马立利.,曹英华.,王建凤.,刘喆.,...&贾丽.(2018).动物源性食品中56种兽药残留物的UPLC-MS/MS高通量分析.分析试验室,37(3),306-310.
MLA	王嘉琦,et al."动物源性食品中56种兽药残留物的UPLC-MS/MS高通量分析".分析试验室 37.3(2018):306-310.